Middle cerebral artery occlusion in the rabbit using selective angiography - Application for assessment of thrombolysis
Middle cerebral artery occlusion in the rabbit using selective angiography - Application for assessment of thrombolysis
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DOI：
10.1161/strokeaha.107.507376
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发表时间：
2008-05-01
期刊：
影响因子：
8.3
通讯作者：
Marder, Victor J.
中科院分区：
文献类型：
--
作者：
Jahan, Reza;Stewart, Daphne;Marder, Victor J.
背景和目的-选择性大脑中动脉（MCA）闭塞的动物模型是评估动脉内（IA）溶栓药物输送的需要。我们描述了一种技术，MCA血栓闭塞在兔闭塞和溶栓recanalization.Methods -股动脉切开后，微导管的实时血管造影文件先进的颈内动脉到MCA。MCA闭塞实现IA凝血酶和再灌注IA plasmin.Results -终末颈内动脉插管成功13只动物中的12。在所有12只动物中诱导稳定（2小时）MCA闭塞并通过血管造影进行验证; 2只动物还存在远端颈内动脉血栓。再通后迅速实现IA纤溶酶在3 3 animal.Conclusions -我们描述了一种新的动物模型，选择性MCA闭塞记录实时血管造影和用于演示再通IA纤溶酶。
Background and Purpose - An animal model of selective middle cerebral artery (MCA) occlusion is needed for evaluation of intra-arterial (IA) delivery of thrombolytic agents. We describe a technique for MCA thrombo-occlusion in the rabbit with real-time angiographic documentation of occlusion and thrombolytic recanalization.Methods - After femoral artery cutdown, a microcatheter was advanced from the internal carotid artery to the MCA. MCA occlusion was achieved by IA thrombin and reperfusion by IA plasmin.Results - The terminal internal carotid artery was successfully catheterized in 12 of 13 animals. Stable (2-hour) MCA occlusion was induced and verified angiographically in all 12 animals; 2 animals also had distal internal carotid artery thrombus. Recanalization was achieved rapidly after IA plasmin in 3 of 3 animals.Conclusions - We describe a new animal model of selective MCA occlusion documented by real-time angiography and used to demonstrate recanalization with IA plasmin.