Immunomodulatory properties and therapeutic application of mesenchymal stem cells
Immunomodulatory properties and therapeutic application of mesenchymal stem cells
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DOI：
10.1111/j.1365-2249.2011.04327.x
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发表时间：
2011-04-01
影响因子：
4.6
通讯作者：
Wang, F-S.
中科院分区：
文献类型：
--
作者：
Shi, M.;Liu, Z-W.;Wang, F-S.
间充质干细胞（Mesenchymal stem cells, MSCs）是从骨髓和几个成人器官和组织中分离出来的多能祖细胞。这些细胞具有显著的免疫抑制特性，可以抑制主要免疫细胞群的增殖和功能，包括T细胞、B细胞和自然杀伤（NK）细胞；调节树突状细胞（dc）的活性；并在体内和体外诱导调节性T细胞。这些独特的性质使间充质干细胞成为临床应用的理想候选免疫抑制剂。MSCs的免疫调节作用是由这些细胞的非特异性抗增殖作用介导的，这种作用依赖于细胞间接触或分泌的可溶性因子，如吲哚胺2,3-双加氧酶（IDO）、前列腺素E-2 （PGE(2)）、一氧化氮（NO）、组织相容性白细胞抗原g （HLA-G）、转化生长因子(TGF)- β、干扰素(IFN)- γ和白细胞介素(IL)-1 β。骨髓间充质干细胞的临床前研究取得了相当大的进展，包括其激活同种异体细胞的能力。本文综述了目前对间充质干细胞的免疫调节特性及其对免疫介导疾病和移植排斥的治疗意义的理解。
P>Mesenchymal stem cells (MSCs) are multi-potent progenitor cells that are isolated from the bone marrow and several adult organs and tissues. These cells possess remarkable immunosuppressive properties and can inhibit the proliferation and function of the major immune cell populations, including T cells, B cells and natural killer (NK) cells; modulate the activities of dendritic cells (DCs); and induce regulatory T cells both in vivo and in vitro. These unique properties make MSCs ideal candidates for clinical application as immunosuppressants. The immunomodulatory effect of MSCs is mediated by a non-specific anti-proliferative action of these cells, which is dependent on cell-cell contact or secreted soluble factors such as indoleamine 2,3-dioxygenase (IDO), prostaglandin E-2 (PGE(2)), nitric oxide (NO), histocompatibility leucocyte antigen-G (HLA-G), transforming growth factor (TGF)-beta, interferon (IFN)-gamma and interleukin (IL)-1 beta. Considerable progress has been obtained in preclinical studies on MSCs, including those on their ability to activate allogeneic cells. This review examines the current understanding of the immunomodulatory properties of MSCs and its therapeutic implication for immune-mediated diseases and transplant rejection.