Neuromodulatory Role of Revascularization Surgery in Moyamoya Disease.
Neuromodulatory Role of Revascularization Surgery in Moyamoya Disease.
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DOI：
10.1016/j.wneu.2016.04.087
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发表时间：
2016-07
影响因子：
2
通讯作者：
Shouhei Noshiro;T. Mikami;Katsuya Komatsu;A. Kanno;R. Enatsu;S. Yazawa;T. Nagamine;M. Matsuhashi;N. Mikuni
中科院分区：
文献类型：
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作者：
Shouhei Noshiro;T. Mikami;Katsuya Komatsu;A. Kanno;R. Enatsu;S. Yazawa;T. Nagamine;M. Matsuhashi;N. Mikuni
BackgroundTo评估烟雾病的搭桥手术的有效性，皮质电图首先evaluated.MethodsA在9例烟雾病患者共13个半球纳入本研究。在额中回放置一个4 × 5的硬膜下电极网格，连续记录旁路手术过程中皮层电图的频谱功率。评估搭桥手术前后频谱功率的变化，并与对照组进行比较。脑血流频谱功率的变化与局部脑血流量的相关性进行了分析。结果搭桥手术前烟雾病患者的β波段/总波段的平均频谱功率比低于对照组（P= 0.027），搭桥手术后其显著性消失（P= 0.800）。烟雾病患者手术后β、γ波段频谱功率水平明显增高（P< 0.001）。β波段的光谱功率的变化与局部脑血流量的变化相关（P= 0.002）。ConclusionsThe光谱功率的β波段上的皮层脑电图局灶性抑制烟雾病患者，抑制是可逆的血管重建手术。烟雾病的狭窄闭塞性缺血改变可能导致神经生理活动的抑制，目前的结果提供了深入了解血管重建手术的潜在神经调节作用。
BackgroundTo evaluate the effectiveness of bypass surgery for moyamoya disease, electrocorticography was first evaluated.MethodsA total of 13 hemispheres in 9 patients with moyamoya disease were included in this study. To record the spectral power of electrocorticography continuously during the bypass procedure, a 4 × 5 subdural electrode grid was placed on the middle frontal gyrus. The changes in spectral power before and after bypass surgery were evaluated and compared with those in a control group. The correlation between changes in spectral power and regional cerebral blood flow was analyzed.ResultsThe average spectral power ratio of the beta band per total band in moyamoya disease before bypass surgery was lower than that of controls (P= 0.027), and the significance disappeared after bypass surgery (P= 0.800). The spectral power levels of the beta band and gamma band were increased in moyamoya disease after bypass surgery (P< 0.001). Changes in spectral power of the beta band correlated with changes in regional cerebral blood flow (P= 0.002).ConclusionsThe spectral power of the beta band on electrocorticography was focally suppressed in patients with moyamoya disease, and the suppression was reversible by revascularization surgery. Steno-occlusive ischemic changes in moyamoya disease might cause suppression of neurophysiologic activity, and the present results provide insight into the potential neuromodulatory role of revascularization surgery.