Stereoselective syntheses of (E)-α,β-dehydroamino acids and (E)-α,β-dehydropeptides by stereospecific dehydration with 1-ethyl-3-(3-dimethyl-aminopropyl)carbodiimide (EDC)
Stereoselective syntheses of (E)-α,β-dehydroamino acids and (E)-α,β-dehydropeptides by stereospecific dehydration with 1-ethyl-3-(3-dimethyl-aminopropyl)carbodiimide (EDC)
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DOI：
10.1055/s-2003-36817
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发表时间：
2003-01-01
影响因子：
2.6
通讯作者：
Ohmizu, H
中科院分区：
文献类型：
--
作者：
Sai, H;Ogiku, T;Ohmizu, H
通过使用1-乙基-3-（3-二甲基氨基丙基）碳二亚胺（EDC）和CuCl 2立体特异性脱水苏型-β-羟基-α-氨基酸衍生物，已经以良好的产率实现了（E）-α，β-脱氢氨基酸和（E）-α，β-脱氢肽的高度立体选择性合成。
Highly stereoselective syntheses of (E)-alpha,beta-dehydroamino acids and (E)-alpha,beta-dehydropeptides have been achieved in good yields by stereospecific dehydration of threo-beta-hydroxy-alpha-amino acid derivatives using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and CuCl2.