White matter abnormalities and illness severity in major depressive disorder
White matter abnormalities and illness severity in major depressive disorder
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DOI：
10.1192/bjp.bp.111.100594
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发表时间：
2012-07-01
影响因子：
10.5
通讯作者：
Fu, Cynthia H. Y.
中科院分区：
文献类型：
--
作者：
Cole, James;Chaddock, Christopher A.;Fu, Cynthia H. Y.
背景脑白质异常与抑郁症的病因学有关;然而，症状的严重程度和白色物质完整性之间的关系目前尚不清楚。目的为了研究重度抑郁症患者和健康对照者的白色物质完整性，方法收集66例复发性抑郁症患者的磁共振弥散张量成像资料，分析其与抑郁症状严重程度的关系。对照组66名年龄、性别和智商得分相匹配的健康人，并进行基于轨迹的空间统计分析。白色物质的完整性和抑郁症的严重程度之间的关系，由贝克抑郁症Inventory. Results抑郁症与广泛的地区减少白色物质的完整性，包括在胼胝体，上级纵束和前冠辐射，与对照组相比，区域。增加症状的严重程度呈负相关的白色物质的完整性，主要是在corpus callosum.ConclusionsWidespread的改变白色物质的完整性是明显的抑郁症。这些异常随着抑郁症状的严重程度增加而加剧。
BackgroundWhite matter abnormalities have been implicated in the aetiology of major depressive disorder; however, the relationship between the severity of symptoms and white matter integrity is currently unclear.AimsTo investigate white matter integrity in people with major depression and healthy controls, and to assess its relationship with depressive symptom severity.MethodDiffusion tensor imaging data were acquired from 66 patients with recurrent major depression and a control group of 66 healthy individuals matched for age, gender and IQ score, and analysed with tract-based spatial statistics. The relationship between white matter integrity and severity of depression, as measured by the Beck Depression Inventory was examined.ResultsDepressive illness was associated with widespread regions of decreased white matter integrity, including regions in the corpus callosum, superior longitudinal fasciculus and anterior corona radiata, compared with the control group. Increasing symptom severity was negatively correlated with white matter integrity, predominantly in the corpus callosum.ConclusionsWidespread alterations in white matter integrity are evident in major depressive disorder. These abnormalities are heightened with increasing severity of depressive symptoms.