Metabolism of ethylene glycol dinitrate (ethylene dinitrate) in the rat following repeated administration
Metabolism of ethylene glycol dinitrate (ethylene dinitrate) in the rat following repeated administration
复制标题
重复给药后大鼠体内乙二醇二硝酸酯（乙二醇二硝酸酯）的代谢
DOI：
10.1136/oem.26.2.150
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发表时间：
1969
期刊：
影响因子：
--
通讯作者：
M. Litchfield
中科院分区：
文献类型：
--
作者：
D. G. Clark;M. Litchfield
Clark, D. G. 和 Litchfield, M. H. (1969)。 J.工业。医学，26，150-155。重复给药后大鼠体内乙二醇二硝酸酯（乙二醇二硝酸酯）的代谢。研究了大鼠重复给药后硝酸乙二醇(EGDN)的体内代谢，以及大鼠和狗重复给药后EDGN和硝化甘油的体外代谢。重复注射后体内外代谢未见变化，EGDN代谢物在尿液中的排泄模式也未发生改变。有人认为，对这些化合物的心血管作用产生的耐受性可能是由于某些生理代偿机制的影响变化，而不是代谢模式的任何变化。
Clark, D. G., and Litchfield, M. H. (1969).Brit. J. industr. Med.,26, 150-155. Metabolism of ethylene glycol dinitrate (ethylene dinitrate) in the rat following repeated administration. The in vivo metabolism of ethylene glycol dinitrate (EGDN) following repeated administration in the rat, and the in vitro metabolism of EDGN and nitroglycerine following repeated administration in the rat and the dog have been studied. No changes were detected in the in vivo or in vitro metabolism after repeated injection, and the pattern of excretion of EGDN metabolites in the urine did not alter. It is suggested that the tolerance that develops to the cardiovascular effects of these compounds may be due to the changing influence of some physiological compensatory mechanisms rather than to any change in the pattern of metabolism.