Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China.
Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China.
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生殖器人乳头瘤病毒感染在夫妻中的传播：中国农村地区的一项基于人群的队列研究。
DOI：
10.1038/srep10986
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发表时间：
2015-07-23
影响因子：
4.6
通讯作者：
Ke Y
中科院分区：
文献类型：
--
作者：
Liu M;He Z;Zhang C;Liu F;Liu Y;Li J;Xu Z;Wang Q;Hang D;Shen N;Pan Y;Guo C;Cai H;Ke Y
HPV在普通人群中的传播动力学研究很少，特别是在中国。我们在2009-2013年期间对来自中国农村的874对年龄在25-65岁之间的夫妇进行了长达7次的生殖器HPV感染状况的随访，每两年进行一次。对一对夫妇的HPV阳性一致性和伴侣的传播率进行评估，并评估相关危险因素。任何、致癌和非致癌HPV的符合率分别为15.52%、16.18%和10.41%。男性对女性的传播率分别为7.11/1000人月、12.13/1000人月和4.77/1000人月。任何、致癌和非致癌HPV的女性对男性的传播率分别为5.56、2.37和17.01/1000人月。对于致癌类型，男性对女性传播的风险显著高于女性对男性传播的风险。然而，对于非致癌类型，男性到女性传播的风险明显低于女性到男性传播的风险。年轻夫妇、HPV持续感染、性伴侣数量较多和性交频率较高与夫妇中HPV传播呈正相关。我们的研究结果表明，在中国农村的男性比西方人群中的男性作为女性宫颈致癌HPV感染的来源发挥更重要的作用。
HPV transmission dynamics have rarely been studied in the general population, especially in China. We followed the genital HPV infection status of both partners in 874 couples aged 25-65 years from rural China for up to 7 bi-annual visits during 2009-2013. The positive HPV concordance and transmission rate for partners in a couple were evaluated and relevant risk factors were assessed. The concordance of any, oncogenic, and non-oncogenic HPV was 15.52%, 16.18% and 10.41%, respectively. Male-to-female transmission rate was 7.11, 12.13 and 4.77/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The female-to-male transmission rate was 5.56, 2.37, and 17.01/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The risk of male-to-female transmission was significantly higher than that of female-to-male transmission for oncogenic types. However, for non-oncogenic types, the risk of male-to-female transmission was significantly lower than that of female-to-male transmission. Younger couples, persistent infection with HPV, higher numbers of sexual partners and higher frequency of sexual intercourse were positively associated with HPV transmission in couples. Our results indicate that men in rural China play a more important role than men in western populations as a source of cervical oncogenic HPV infection in women.