Phototrichogram analysis of Japanese female subjects with chronic diffuse hair loss
Phototrichogram analysis of Japanese female subjects with chronic diffuse hair loss
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DOI：
10.1046/j.1523-1747.2003.12184.x
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发表时间：
2003-06-01
影响因子：
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通讯作者：
Ogawa, H
中科院分区：
文献类型：
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作者：
Ueki, R;Tsuboi, R;Ogawa, H
对101例日本女性弥漫性慢性脱发患者和58例健康女性志愿者的头发生长模式进行了无创性定量研究，确定了头发生长的关键参数。在头皮顶区修剪毛发后0小时和48小时行三次摄影检查。然后测量切除的毛发的轴径。多元回归分析表明，毛发密度、毛发直径、短毛率和毛发生长率对女性弥漫性脱发分级的重要性依次为显著，而不是生发比率。应用聚类分析，将主诉弥漫性脱发的受试者的头发生长模式分为6个异常组(n=60)、2个临界组(n=21)和1个正常组(n=20)。通过肉眼观察判断为正常的对照受试者，实际上包括两名毛发生长模式边缘的受试者和一名异常受试者。大多数异常人群具有女性雄激素性脱发的特征。然而，在日本女性受试者中，头发密度下降但没有鹿角状头发变化的头发模式是最普遍和最明显的慢性弥漫性脱发模式。照片三色图结合头发直径的测量，是评估头发生长模式的准确工具，特别是在检测指示弥漫性脱发早期阶段的轻微变化方面。
Hair growth patterns of 101 Japanese female subjects with diffuse, chronic hair loss and 58 healthy Japanese female volunteers were categorized into subgroups using noninvasive quantitative methods after determining the key parameters of hair growth. Phototrichogram was performed at 0 and 48 h after clipping hairs in the parietal region of the scalp. Shaft diameters of the excised hairs were then measured. Multiple regression analysis indicated that hair densities, hair diameters, short hair ratios, and hair growth rates, but not anagen hair ratios, were significant, in order of decreasing importance, for grading female diffuse alopecia. Using cluster analysis, hair growth patterns among subjects complaining of diffuse hair loss were divided into six abnormal groups (n=60), two borderline groups (n=21), and one normal group (n=20). The control subjects judged to be normal by macroscopic observation, actually included two subjects with borderline hair growth patterns and one abnormal subject. Most of the abnormal groups shared features of female androgenetic alopecia. Hair patterns showing a decrease in hair density but without vellus hair change, however, emerged as the most prevalent and distinct pattern of chronic diffuse hair loss among the Japanese female subjects. The phototrichogram, combined with the measurement of hair diameters, is an accurate tool for assessing hair growth patterns, especially in detecting the slight changes indicative of the early phase of diffuse alopecia.