Central and peripheral hemodynamics in exercising humans: leg vs arm exercise
Central and peripheral hemodynamics in exercising humans: leg vs arm exercise
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DOI：
10.1111/sms.12604
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发表时间：
2015-12-01
影响因子：
4.1
通讯作者：
Boushel, R.
中科院分区：
文献类型：
--
作者：
Calbet, J. A. L.;Gonzalez-Alonso, J.;Boushel, R.
在人类中，已知手臂运动比腿部运动引起更大的动脉血压（BP）升高。然而，心输出量随运动强度的分布对局部血管传导性（VC）的精确调节仍不清楚。在9只雄性动物中，评估了递增直立臂摇动（AC）和腿部蹬踏（LP）至力竭（W-max）期间的血流动力学反应。AC期间的全身VC、峰值心输出量（Q（峰值））（吲哚菁绿色）和每搏输出量（SV）比LP期间分别低18%、23%和20%。在最大AC期间，平均BP、心率-血压乘积和相关心肌需氧量分别比LP高22%、12%和14%。在W-max时，躯干VC降低至相似值。在W-max，肌肉质量标准化VC和分数O-2提取低于手臂比腿部肌肉。然而，在AC期间，通过提高灌注压以增加O-2输送来补偿这一点，从而允许两个肢体中每kg肌肉质量的类似峰值VO 2。总之，尽管在手臂摇动期间的Q（峰值）较低，但心血管应变远高于腿部踩踏期间。在递增运动到力竭的过程中，区域电导的调整主要取决于运动的相对强度，并且具有肢体特异性。
In humans, arm exercise is known to elicit larger increases in arterial blood pressure (BP) than leg exercise. However, the precise regulation of regional vascular conductances (VC) for the distribution of cardiac output with exercise intensity remains unknown. Hemodynamic responses were assessed during incremental upright arm cranking (AC) and leg pedalling (LP) to exhaustion (W-max) in nine males. Systemic VC, peak cardiac output (Q(peak)) (indocyanine green) and stroke volume (SV) were 18%, 23%, and 20% lower during AC than LP. The mean BP, the rate-pressure product and the associated myocardial oxygen demand were 22%, 12%, and 14% higher, respectively, during maximal AC than LP. Trunk VC was reduced to similar values at W-max. At W-max, muscle mass-normalized VC and fractional O-2 extraction were lower in the arm than the leg muscles. However, this was compensated for during AC by raising perfusion pressure to increase O-2 delivery, allowing a similar peak VO2 per kg of muscle mass in both extremities. In summary, despite a lower Q(peak) during arm cranking the cardiovascular strain is much higher than during leg pedalling. The adjustments of regional conductances during incremental exercise to exhaustion depend mostly on the relative intensity of exercise and are limb-specific.