Epigenetics: Demethylation links cell fate and cancer
Epigenetics: Demethylation links cell fate and cancer
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DOI：
10.1038/nrc2948
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发表时间：
2010-10
影响因子：
78.5
通讯作者：
M. Swami
中科院分区：
文献类型：
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作者：
M. Swami
斑马鱼胚胎中肿瘤抑制因子APC的缺失导致DNA去甲基化酶组分的上调和关键肠细胞命运基因的启动子低甲基化，导致肠祖细胞维持在未分化状态。
Loss of the tumour suppressor APC in zebrafish embryos leads to upregulation of DNA demethylase components and promoter hypomethylation of key intestinal cell fate genes, leading to the maintenance of intestinal progenitor cells in an undifferentiated state.