LYMPHOTOXIN-BETA, A NOVEL MEMBER OF THE TNF FAMILY THAT FORMS A HETEROMERIC COMPLEX WITH LYMPHOTOXIN ON THE CELL-SURFACE
LYMPHOTOXIN-BETA, A NOVEL MEMBER OF THE TNF FAMILY THAT FORMS A HETEROMERIC COMPLEX WITH LYMPHOTOXIN ON THE CELL-SURFACE
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DOI：
10.1016/0092-8674(93)90574-a
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发表时间：
1993-03-26
期刊：
影响因子：
64.5
通讯作者：
WARE, CF
中科院分区：
文献类型：
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作者：
BROWNING, JL;NGAMEK, A;WARE, CF
淋巴因子肿瘤坏死因子（TNF）作为炎症反应的诱导剂具有明确的作用;然而，结构相关分子光毒素（LT α）的功能尚不清楚。LT α存在于活化的T、B和LAK细胞的表面上，作为与33 kd糖蛋白的复合物，并且克隆编码相关蛋白的cDNA，称为光毒素β（LT β），揭示其为与TNF、LT α和CD 40受体的配体具有显著同源性的II型膜蛋白。LT β基因被发现位于主要组织相容性复合体（MHC）中TNF-LT位点旁边，该区域可能与自身免疫性疾病有关。这些观察结果提出了一种可能性，即表面L α-LT β复合物可能在免疫调节中具有不同于归因于TNF的功能的特定作用。
The lymphokine tumor necrosis factor (TNF) has a well-defined role as an inducer of inflammatory responses; however, the function of the structurally related molecule lymphotoxin (LTalpha) is unknown. LTalpha is present on the surface of activated T, B, and LAK cells as a complex with a 33 kd glycoprotein, and cloning of the cDNA encoding the associated protein, called lymphotoxin beta (LTbeta), revealed it to be a type II membrane protein with significant homology to TNF, LTalpha, and the ligand for the CD40 receptor. The gene for LTbeta was found next to the TNF-LT locus in the major histocompatibility complex (MHC), a region of the MHC with possible linkage to autoimmune disease. These observations raise the possibility that a surface LTalpha-LTbeta complex may have a specific role in immune regulation distinct from the functions ascribed to TNF.