Oxidative cyclisation of o-phenolic oxime-acid derivatives using hypervalent iodine reagent: asymmetric induction at the γ-position to the carbonyl group of chiral o-phenolic oxime-ester
Oxidative cyclisation of o-phenolic oxime-acid derivatives using hypervalent iodine reagent: asymmetric induction at the γ-position to the carbonyl group of chiral o-phenolic oxime-ester
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DOI：
10.1039/c39940000443
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
M. Murakata;Kohei Yamada;O. Hoshino
中科院分区：
文献类型：
--
作者：
M. Murakata;Kohei Yamada;O. Hoshino
使用高价碘试剂，通过邻酚肟酯 5 的分子内氧化环化，以 82% 非对映异构体过量 (d.e.)（87% 产率）在手性酯的羰基的 γ 位进行有效的不对称诱导，得到手性螺异恶唑啉。
An efficient asymmetric induction at the γ-position to the carbonyl group of the chiral ester took place in 82% diastereoisomeric excess (d.e.)(87% yield) to afford chiral spiroisoxazoline by intramolecular oxidative cyclisation of o-phenolic oxime-ester 5 using hypervalent iodine reagent.