X-chromosome inactivation: does it occur at the same time in all cells of the embryo?
X-chromosome inactivation: does it occur at the same time in all cells of the embryo?
复制标题
X染色体失活：它是否同时发生在胚胎的所有细胞中？
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
W. Whitten
中科院分区：
文献类型：
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作者：
M. Deol;W. Whitten
在哺乳动物的杂合雌性中，与许多性别连锁基因相关的马赛克表型通常被认为是由于在发育过程中每个细胞中的一条X染色体随机失活所致1,2。灭活被认为发生在胚胎生命的早期，几乎同时发生在胚胎的所有细胞中。我们先前已经表明，在老鼠的视网膜黑素细胞中，这一过程可能比以前认为的要晚得多。现在，我们又对迁移的黑素细胞进行了类似的研究，这些细胞的起源不同，开始形成色素的时间也较晚。
THE mosaic phenotype associated with many sex-linked genes in heterozygous females in mammals is generally believed to result from the random inactivation of one X chromosome in each cell during development1,2. Inactivation is thought to occur quite early in embryonic life and more or less at the same time in all cells of the embryo3. Having earlier4 shown that in the retinal melanocytes of the mouse it probably occurs much later than had formerly been thought, we have now carried out a similar study on migratory melanocytes, which are of a different origin and which start forming pigment later.