Network motifs and their origins
Network motifs and their origins
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DOI：
10.1371/journal.pcbi.1006749
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发表时间：
2019-04
影响因子：
4.3
通讯作者：
L. Stone;D. Simberloff;Yael A. Artzy‐Randrup
中科院分区：
文献类型：
--
作者：
L. Stone;D. Simberloff;Yael A. Artzy‐Randrup
作者摘要 现代网络科学是一个令人兴奋的新研究领域，它在过去 20 年里改变了复杂系统的研究。特别令人感兴趣的是识别可能嵌入到更大网络中的小型“网络主题”，并表明进化设计原则的存在或对系统范围的动态具有过度影响力的作用。基序是互连或子图的模式，它们在观察到的网络中出现的频率明显高于在兼容的随机网络中出现的频率。网络基序的概念由 Milo、Alon 及其同事于 2002 年引入系统生物学，迅速彻底改变了该领域，并从那时起在更广泛的科学领域产生了巨大影响。在这里，我们认为用于检测主题的相同概念和工具在上世纪几十年的生态文献中是众所周知的，但这一事实通常没有被认识到。我们回顾了网络主题的早期历史、它们在数学文献中的演变以及它们最近的重新发现。
Author summary Modern network science is a new and exciting research field that has transformed the study of complex systems over the last 2 decades. Of particular interest is the identification of small “network motifs” that might be embedded in a larger network and that indicate the presence of evolutionary design principles or have an overly influential role on system-wide dynamics. Motifs are patterns of interconnections, or subgraphs, that appear in an observed network significantly more often than in compatible randomized networks. The concept of network motifs was introduced into Systems Biology by Milo, Alon and colleagues in 2002, quickly revolutionized the field, and it has had a huge impact in wider scientific domains ever since. Here, we argue that the same concept and tools for the detection of motifs were well known in the ecological literature decades into the last century, a fact that is generally not recognized. We review the early history of network motifs, their evolution in the mathematics literature, and their recent rediscoveries.