Development of pluripotent hematopoietic progenitor cells in the human fetus.
Development of pluripotent hematopoietic progenitor cells in the human fetus.
复制标题
人类胎儿多能造血祖细胞的发育。
作者：
I. Hann;M. Bodger;A. Hoffbrand
Pluripotent hematopoietic progenitor cells (CFU-GEMM), myeloid progenitor cells (CFU-GM), and erythroid progenitors (BFU-E) were studied in midtrimester human fetuses using the mixed colony assay. All three progenitor cell populations were detected at high levels in the fetal liver from 12 to 23 wk of gestation. Stem cells were first observed in the bone marrow at 15-16 wk of gestation, although bone marrow cultures from earlier fetuses showed heavy growths of stromal cells. Spleen cultures first showed growth of stem cells at 18-19 wk, but fetal thymus showed no hematopoietic activity. Peripheral blood from four fetuses aged 13, 18, 20, and 21 wk showed very high levels of all 3 progenitor cells. The results demonstrate that hematopoietic development in the human fetus parallels that of the mouse. The observation that stromal cell development in the bone marrow precedes the appearance of hematopoietic progenitor cells suggests that they may be closely involved in stem cell growth.
人类新生儿血液中循环红系祖细胞的表征。
DOI：
--
发表时间：
1981
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Tchernia,G;Mielot,F;Coulombel,L;Mohandas,N
通讯作者：
Mohandas,N
人体体外微环境的研究。
DOI：
10.1007/978-3-642-68761-7_67
发表时间：
1983
期刊：
Haematology and blood transfusion
影响因子：
--
作者：
Singer,JW;Keating,A
通讯作者：
Keating,A