High serum IgG4 concentrations in patients with sclerosing pancreatitis.
High serum IgG4 concentrations in patients with sclerosing pancreatitis.
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DOI：
10.1056/nejm200103083441005
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发表时间：
2001-03-08
影响因子：
158.5
通讯作者：
Kiyosawa, K
中科院分区：
文献类型：
--
作者：
Hamano, H;Kawa, S;Kiyosawa, K
背景资料：硬化性胰腺炎是胰腺炎的一种独特形式，其特征在于主胰管不规则狭窄、胰腺淋巴浆细胞性炎症和高丙种球蛋白血症，并且对糖皮质激素治疗有反应。初步研究表明，血清IgG 4浓度升高，在这种疾病，但不是在其他疾病的胰腺或胆道。方法：我们采用单向免疫扩散和酶联免疫吸附试验检测了20例硬化性胰腺炎患者、20例年龄和性别匹配的正常受试者、154例胰腺癌、普通慢性胰腺炎、原发性胆汁性肝硬化、原发性硬化性胆管炎或舍格伦综合征。通过单克隆类风湿因子酶联免疫吸附试验测定免疫复合物和免疫复合物IgG 4亚类的血清浓度。硬化性胰腺炎患者血清IgG 4浓度中位数为663 mg/dl第5和95次月经周期分别为136和1150天，而正常人为51 mg/dl（第5和95次月经周期分别为15和128天）（P
Background: Sclerosing pancreatitis is a unique form of pancreatitis that is characterized by irregular narrowing of the main pancreatic duct, lymphoplasmacytic inflammation of the pancreas, and hypergammaglobulinemia and that responds to glucocorticoid treatment. Preliminary studies suggested that serum IgG4 concentrations are elevated in this disease but not in other diseases of the pancreas or biliary tract.Methods: We measured serum IgG4 concentrations using single radial immunodiffusion and an enzyme-linked immunosorbent assay in 20 patients with sclerosing pancreatitis, 20 age- and sex-matched normal subjects, and 154 patients with pancreatic cancer, ordinary chronic pancreatitis, primary biliary cirrhosis, primary sclerosing cholangitis, or Sjogren's syndrome. Serum concentrations of immune complexes and the IgG4 subclass of immune complexes were determined by means of an enzyme-linked immunosorbent assay with monoclonal rheumatoid factor.Results: The median serum IgG4 concentration in the patients with sclerosing pancreatitis was 663 mg per deciliter (5th and 95th percentiles, 136 and 1150), as compared with 51 mg per deciliter (5th and 95th percentiles, 15 and 128) in normal subjects (P