Atrophic autoimmune thyroiditis: relationship between the clinical state and intrathyroidal iodine as measured in vivo in man.
Atrophic autoimmune thyroiditis: relationship between the clinical state and intrathyroidal iodine as measured in vivo in man.
复制标题
萎缩性自身免疫性甲状腺炎：临床状态与人体体内测定的甲状腺内碘之间的关系。
DOI：
10.1210/jcem-53-3-476
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Y. Michotte
中科院分区：
文献类型：
--
作者：
M. Jonckheer;L. Vanhaelst;F. Deconinck;Y. Michotte
The intrathyroidal iodine (ITI) was measured by means of the x-ray fluorescence method in 58 patients suffering from atrophic autoimmune thyroiditis (AAT). They were divided into 4 groups according to their basal T4, basal TSH, and the peak TSH response after TRH administration. Forty-eight normal subjects served as controls. A progressive fall of ITI was found, with less ITI in the first grade AAT patients as compared to the controls. A negative correlation between basal TSH and ITI could be shown. These data support the concept of a graded evolution of AAT, linking the clinical state to the ITI. The results also suggest that, with the hemagglutination techniques used for the determination of antithyroglobulin antibodies and antithyroid microsomal antibodies, positively at a dilution of 1:25 and 1:100, respectively, should be regraded as significant.
