Invasive Breast Cancer: Relationship between Shear-wave Elastographic Findings and Histologic Prognostic Factors
Invasive Breast Cancer: Relationship between Shear-wave Elastographic Findings and Histologic Prognostic Factors
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DOI：
10.1148/radiol.12111317
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发表时间：
2012-06-01
期刊：
影响因子：
19.7
通讯作者：
Thompson, Alastair
中科院分区：
文献类型：
--
作者：
Evans, Andrew;Whelehan, Patsy;Thompson, Alastair
目的：比较浸润性乳腺癌的组织学预后特征与剪切波弹性成像测量的平均硬度。材料和方法：这项回顾性研究免于伦理委员会审查。获得患者同意使用图像进行研究。研究组包括101名连续女性（年龄范围，38-91岁），在2010年4月至2011年3月进行的常规乳腺超声检查（US）中发现了实体病变，随后在组织学检查中证实为浸润性癌症。在两个正交平面上获得每个病变的四个弹性成像图像，并从每个图像中获得平均刚度值。使用手术后的组织学结果进行比较，即组织学分级、肿瘤类型、浸润大小、血管浸润状态和淋巴结状态。通过一般线性模型和多元回归分析研究平均硬度与组织学参数之间的关系。高组织学分级（P < .0001），大侵入尺寸（P < .0001），淋巴结受累（P < .0001）、肿瘤类型（P < .0001）和血管浸润（P = .0077）均显示与高平均硬度值有统计学显著正相关。多元线性回归表明，浸润性大小是最强的病理决定因素的平均硬度（P <0.0001），与组织学分级也有显着的影响（P = 0.022）。结论：在这项研究中，乳腺癌的剪切波弹性成像具有较高的平均硬度值有较差的预后特征。(c)RSNA，2012年
Purpose: To compare the histologic prognostic feature of invasive breast cancer with mean stiffness as measured with shear-wave elastography.Materials and Methods: This retrospective study was exempted from ethical committee review. Patient consent for use of images for research was obtained. The study group comprised 101 consecutive women (age range, 38-91 years) with solid lesions identified during routine breast ultrasonography (US) performed between April 2010 and March 2011 and subsequently confirmed at histologic examination to be invasive cancers. Four elastographic images in two orthogonal planes were obtained of each lesion, and mean stiffness values were obtained from each image. Histologic findings following surgery were used for comparison, namely histologic grade, tumor type, invasive size, vascular invasion status, and lymph node status. Relationship between mean stiffness and histologic parameters was investigated by using a general linear model and multiple regression analysis.Results: High histologic grade (P < .0001), large invasive size (P < .0001), lymph node involvement (P < .0001), tumor type (P < .0001), and vascular invasion (P = .0077) all showed statistically significant positive association with high mean stiffness values. Multiple linear regression indicated that invasive size is the strongest pathologic determinant of mean stiffness (P < .0001), with histologic grade also having significant influence (P = .022).Conclusion: In this study, breast cancers with higher mean stiffness values at shear-wave elastography had poorer prognostic features. (c) RSNA, 2012