AcK-knowledge reversible acetylation.
AcK-knowledge reversible acetylation.
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DOI：
10.1126/stke.2452004pe42
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发表时间：
2004-08-03
期刊：
影响因子：
--
通讯作者：
Yao, Tso-Pang
中科院分区：
文献类型：
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作者：
Cohen, Todd;Yao, Tso-Pang
1966年，组蛋白被确定为第一个可逆乙酰化的蛋白质。随后30年的组蛋白乙酰化研究对于阐明基因转录和染色质重塑如何在分子水平上进行调控至关重要。然而，对组蛋白的这种中心关注也限制了我们对可逆乙酰化的理解，从而限制了催化这一反应的酶，主要与染色质有关的细胞过程。可逆乙酰化的研究已或多或少地成为组蛋白乙酰化的代名词。最近的发展-包括检测乙酰化蛋白质的能力的提高，新的乙酰化转移酶和脱乙酰酶的表征，以及这些酶的特定抑制剂的鉴定-揭示了这个组蛋白中心范式可能只反映了可逆乙酰化调节的细胞过程的一小部分。新的研究发现，可逆乙酰化在许多不同的领域发挥了意想不到的作用，从而确立了蛋白质乙酰化是一种高度通用的信号修饰，具有基因转录和染色质重塑以外的功能。
In 1966, the histone was identified as the first protein subject to reversible acetylation. The ensuing 30 years of research on histone acetylation has been critical for elucidating how gene transcription and chromatin remodeling are regulated at the molecular level. This central focus on histones, however, has also restricted our understanding of reversible acetylation, and therefore the enzymes that catalyze this reaction, to cellular processes predominantly associated with chromatin. The study of reversible acetylation has become more or less synonymous with histone acetylation. Recent developments-including increased ability to detect acetylated proteins, the characterization of novel acetyltransferases and deacetylases, and the identification of specific inhibitors for these enzymes-have revealed that this histone-central paradigm probably reflects only a fraction of the cellular processes regulated by reversible acetylation. New studies have uncovered unexpected roles for reversible acetylation in many diverse areas, thereby establishing protein acetylation as a highly versatile signaling modification that has functions beyond gene transcription and chromatin remodeling.