Impact of Advancing Age on the Status and Risk of Postoperative Infections After Liver Resection
Impact of Advancing Age on the Status and Risk of Postoperative Infections After Liver Resection
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高龄对肝切除术后感染状况和风险的影响
DOI：
10.1007/s00268-021-06236-8
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发表时间：
2021
期刊：
影响因子：
2.6
通讯作者：
Kubo S.
中科院分区：
文献类型：
--
作者：
Kinoshita M;Shinkawa H;Kabata D;Tanaka S;Takemura S;Amano R;Kimura K;Ohira G;Nishio K;Kubo S.
背景尽管近年来接受肝切除术的老年患者越来越多，但年龄增长对术后感染（PI）发生率和风险的影响仍不清楚。本研究的目的是调查的影响，提前年龄对PI的发病率和status.MethodsThis回顾性研究包括744例肝切除术，胆道重建或其他器官的联合切除。多变量分析与限制性三次样条被用来评估的影响，提前年龄对PI的，并确定其与PI的风险在接受开放式和腹腔镜肝切除术（OLR和LLR，分别）。结果多变量分析表明，提前年龄与增加PI的风险（P= 0.017）。样条曲线显示，PI的比值比从大约65岁开始急剧增加。评估PI亚类别的未调整限制性三次样条表明，年龄的增加与器官/空间手术部位感染和败血症的风险增加有关（分别为P= 0.064和0.048）。多变量分析显示，与OLR相比，LLR与较低的PI风险相关（P= 0.025），而LLR较低的PI风险并没有被年龄的增长所掩盖（P= 0.29）。
BackgroundDespite the recently increasing number of elderly patients undergoing liver resection, the impact of advancing age on postoperative infections (PIs) incidence and risk remains unclear. This study aimed to investigate the impact of advancing age on PIs incidence and status.MethodsThis retrospective study included 744 patients undergoing liver resection without biliary reconstruction or combined resection of other organs. Multivariable analysis with a restricted cubic spline was used to evaluate the impact of advancing age on PIs and to determine its association with PIs risk in patients undergoing open and laparoscopic liver resection (OLR and LLR, respectively).ResultsMultivariable analysis demonstrated that advancing age was significantly associated with increased PIs risk (P= 0.017). The spline curve showed that the odds ratio for PIs sharply increased starting approximately at 65 years of age. Unadjusted restricted cubic splines assessing the subcategories of PIs demonstrated that advancing age was associated with increased risks of organ/space surgical site infection and sepsis (P= 0,064 and 0.048, respectively). Multivariable analysis revealed that LLR was associated with the lower PIs risk compared with OLR (P= 0.025), whereas the lower PIs risk with LLR was not significantly obscured by advancing age (P= 0.29).ConclusionsAdvancing age was associated with increased risk of PIs, including organ/space surgical site infections and sepsis, after liver resection especially in patients aged ≥ 65 years.
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影响因子：
3.2
作者：
Xourafas, Dimitrios;Pawlik, Timothy M.;Cloyd, Jordan M.
通讯作者：
Cloyd, Jordan M.
可行地使用估计身高来预测长期护理老人的老年营养风险指数的结果
影响因子：
3.5
作者：
E. Cereda;D. Limonta;C. Pusani;Alfredo Vanotti
通讯作者：
Alfredo Vanotti
影响因子：
1.6
作者：
Sutherland AG;Cook A;Miller C;Duncan L;Yuecel R;Heys SD;Hutchison JD;Liversidge J
通讯作者：
Liversidge J
肝细胞癌肝切除术后手术部位感染的危险因素
DOI：
--
发表时间：
2007
期刊：
影响因子：
--
作者：
H.;Amano;R.;Man;T.;Itamoto;Y.;Tanimoto;I.;Ushitora;A.;Oshita;H.;Ohdan;H.;Tashiro;T.;Asahara
通讯作者：
Asahara
影响因子：
15.3
作者：
Nanashima, Atsushi;Arai, Junichi;Nagayasu, Takeshi
通讯作者：
Nagayasu, Takeshi