Tracking regional tissue volume and function change in lung using image registration.
Tracking regional tissue volume and function change in lung using image registration.
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使用图像配准跟踪肺部的区域组织体积和功能变化。
DOI：
10.1155/2012/956248
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发表时间：
2012
影响因子：
7.6
通讯作者：
Reinhardt,JosephM
中科院分区：
文献类型：
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作者：
Cao,Kunlin;Christensen,GaryE;Ding,Kai;Du,Kaifang;Raghavan,MaghavanL;Amelon,RyanE;Baker,KimberlyM;Hoffman,EricA;Reinhardt,JosephM
我们之前已经证明，在正常志愿者的支气管镜手术过程中，支气管肺泡灌洗液 (BAL) 会在 24 小时内重新分布和重新吸收。在这项工作中，我们利用图像匹配程序将液体重新分布和重吸收与局部肺功能的变化相关联。本研究使用了六名人类受试者的肺部 CT 数据集。每个受试者在 BAL 手术前后的四个时间点进行扫描。进行图像配准以对齐不同时间点和不同通货膨胀水平的图像。由此产生的密集位移场用于跟踪组织体积变化并定量揭示局部实质组织的变形模式。配准精度通过测量地标匹配误差来评估，误差约为 1mm。结果表明，定量评估的液体量与支气管镜医生报告的全肺未检索 BAL 量非常吻合（平方线性相关系数为 0.81）。基线时和24小时后肺组织体积的平均差异约为2%，这表明24小时后肺中的BAL液体几乎被吸收。局部肺功能变化与 BAL 液体的存在相关，并且随着液体被重新吸收，区域功能恢复到基线。
We have previously demonstrated the 24‐hour redistribution and reabsorption of bronchoalveolar lavage (BAL) fluid delivered to the lung during a bronchoscopic procedure in normal volunteers. In this work we utilize image‐matching procedures to correlate fluid redistribution and reabsorption to changes in regional lung function. Lung CT datasets from six human subjects were used in this study. Each subject was scanned at four time points before and after BAL procedure. Image registration was performed to align images at different time points and different inflation levels. The resulting dense displacement fields were utilized to track tissue volume changes and reveal deformation patterns of local parenchymal tissue quantitatively. The registration accuracy was assessed by measuring landmark matching errors, which were on the order of 1 mm. The results show that quantitative‐assessed fluid volume agreed well with bronchoscopist‐reported unretrieved BAL volume in the whole lungs (squared linear correlation coefficient was 0.81). The average difference of lung tissue volume at baseline and after 24 hours was around 2%, which indicates that BAL fluid in the lungs was almost absorbed after 24 hours. Regional lung‐function changes correlated with the presence of BAL fluid, and regional function returned to baseline as the fluid was reabsorbed.