Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease
Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease
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DOI：
10.1212/wnl.57.4.728
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发表时间：
2001-08-28
期刊：
影响因子：
9.9
通讯作者：
Homburger, HA
中科院分区：
文献类型：
--
作者：
Aksamit, AJ;Preissner, CM;Homburger, HA
对克雅氏病(CJD)或其他最初被认为是CJD的快速痴呆患者的脑脊液14-3-3和神经元特异性烯醇化酶(NSE)蛋白进行了定量检测。在152名研究对象中，31名患者被诊断为CJD。CSF14-3-3>8 ng/m L与CJD相关。脑脊液NSE<30 ng/m L和14-3-3<8 ng/m L使CJD的诊断不太可能，但不排除它。
CSF 14-3-3 and neuron-specific enolase (NSE) proteins were quantitated from patients who had Creutzfeldt-Jakob disease (CJD) or other rapidly dementing disorders initially considered to be CJD. Thirty-one patients were diagnosed as having CJD among 152 studied. CSF 14-3-3 values more than 8 ng/mL correlated with CJD. CSF NSE values less than 30 ng/mL and 14-3-3 values less than 8 ng/mL made a diagnosis of CJD unlikely, but did not exclude it.