The Ginkgo biloba extract (EGb 761) provides a neuroprotective effect on retinal ganglion cells in a rat model of chronic glaucoma
The Ginkgo biloba extract (EGb 761) provides a neuroprotective effect on retinal ganglion cells in a rat model of chronic glaucoma
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DOI：
10.1076/ceyr.28.3.153.26246
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发表时间：
2004-03-01
影响因子：
2
通讯作者：
Shiraga, F
中科院分区：
文献类型：
--
作者：
Hirooka, K;Tokuda, M;Shiraga, F
目的。研究银杏叶提取物（egb761）对慢性中度眼压升高大鼠视网膜神经节细胞神经毒性的影响。烧灼三根外膜血管可引起大鼠单侧慢性中度眼压升高。在5个月的时间里，用和不用EGb 761测量继发性变性。5个月时，用快速蓝色示踪剂标记视网膜神经节细胞，并将其应用于上丘。通过计数整个视网膜中快速蓝色标记的细胞来估计存活的视网膜神经节细胞密度。与正常IOP的对侧对照眼相比，慢性中度IOP升高的外周视网膜视网膜神经节细胞损失在未治疗组5个月时为29.8+/-1.5% (n=5)，而EGb 761治疗组5个月时为4.6+/-4.5% （n=5）。EGb 761预处理和早期后处理对慢性青光眼大鼠模型具有有效的神经保护剂作用。
Purpose. To investigate the effect of Ginkgo biloba extract (EGb 761) against neurotoxicity of retinal ganglion cells of rats with chronic moderately elevated intraocular pressure (IOP).Methods. Unilateral chronic moderately elevated IOP was produced in rats by cautery of three episcleral vessels. Secondary degeneration was measured with and without EGb 761 for 5 months. At 5 months, retinal ganglion cells were labeled with a fast blue tracer applied to both superior colliculi. Densities of surviving retinal ganglion cells were estimated by counting fast blue labeled cells in whole mounted retinas.Results. When compared with their contralateral control eyes with normal IOP, in the peripheral retina, retinal ganglion cell loss in eyes with chronic, moderately elevated IOP was 29.8+/-1.5% (n=5) at 5 months in untreated animals and 4.6+/-4.5% (n=5) at 5 months in treated animals with EGb 761.Conclusions. Pretreatment and early posttreatment with EGb 761 is an effective neuroprotectant in a rat model of chronic glaucoma.