Molecular imaging of gliomas with PET: Opportunities and limitations
Molecular imaging of gliomas with PET: Opportunities and limitations
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DOI：
10.1093/neuonc/nor054
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发表时间：
2011-08-01
期刊：
影响因子：
15.9
通讯作者：
Tonn, Joerg-Christian
中科院分区：
文献类型：
--
作者：
la Fougere, Christian;Suchorska, Bogdana;Tonn, Joerg-Christian
神经影像能够对神经胶质瘤进行无创评估，并被认为是个体化治疗和患者管理的关键因素之一，因为治疗计划和治疗反应评估需要准确诊断和划分活肿瘤组织。 MRI 和 CT 等传统成像技术可揭示形态信息，但对于评估有关肿瘤生物学和活性的更具体和可重复的信息价值有限。 PET 分子成像越来越多地应用于神经肿瘤学，因为它提供了肿瘤的额外代谢信息，既可用于患者管理，也可用于评估新开发的疗法。不同的分子过程被认为是有用的，例如葡萄糖消耗、氨基酸转运蛋白的表达、增殖率、膜生物合成和缺氧。因此，PET 可能有助于神经肿瘤学家通过“真实的分子成像”进一步了解肿瘤生物学，并了解与治疗相关的现象。这篇综述描述了 PET 采集方法以及用于对神经胶质瘤生物过程进行成像的示踪剂。此外，它还考虑了 PET 对当前可用放射性示踪剂的使用的临床影响，这些放射性示踪剂被证明对于区分肿瘤和非肿瘤组织、肿瘤分级、治疗反应的确定以及提供进一步发展的前景具有潜在的价值。
Neuroimaging enables the noninvasive evaluation of glioma and is considered to be one of the key factors for individualized therapy and patient management, since accurate diagnosis and demarcation of viable tumor tissue is required for treatment planning as well as assessment of treatment response. Conventional imaging techniques like MRI and CT reveal morphological information but are of limited value for the assessment of more specific and reproducible information about biology and activity of the tumor. Molecular imaging with PET is increasingly implemented in neuro-oncology, since it provides additional metabolic information of the tumor, both for patient management as well as for evaluation of newly developed therapeutics. Different molecular processes have been proposed to be useful, like glucose consumption, expression of amino acid transporters, proliferation rate, membrane biosynthesis, and hypoxia. Thus, PET might help neuro-oncologists gain further insights into tumor biology by "true molecular imaging" as well as understand treatment-related phenomena.This review describes the method of PET acquisition as well as the tracers used to image biological processes in gliomas. Furthermore, it considers the clinical impact of PET on the use of currently available radiotracers, which were shown to be potentially valuable for discrimination between neoplastic and nonneoplastic tissue, as well as on tumor grading, determinination of treatment response, and providing an outlook toward further developments.