Serum apoB levels independently predict the development of non-alcoholic fatty liver disease: A 7-year prospective study
Serum apoB levels independently predict the development of non-alcoholic fatty liver disease: A 7-year prospective study
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血清 apoB 水平独立预测非酒精性脂肪肝的发展：一项为期 7 年的前瞻性研究。
DOI：
10.1111/liv.13363
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发表时间：
2017-08-01
影响因子：
6.7
通讯作者：
Xu, Chengfu
中科院分区：
文献类型：
--
作者：
Wang, Jinghua;Zhu, Wanlin;Xu, Chengfu
背景与目的：横断面研究表明，载脂蛋白 B (apoB) 与非酒精性脂肪肝 (NAFLD) 的患病率呈正相关。本研究旨在探讨中国人群血清apoB水平与NAFLD发展之间的前瞻性关系。方法：本前瞻性研究纳入了7077名最初无NAFLD的参与者。计算具有不同基线血清 apoB 五分位数的参与者的 NAFLD 发病率。进行 Cox 比例风险回归分析来计算 NAFLD 事件的风险。结果：在 41 555 人年的随访中，发现了 1139 例 NAFLD 事件病例。基线 apoB 水平呈线性且与 NAFLD 发病率呈正相关。对于基线 apoB 水平在五分位数 1-5 的参与者，每 1000 人年随访中的发病率分别为 16.99、22.63、24.73、37.51 和 42.77。与基线 apoB 水平处于五分位数 1 的参与者相比，基线水平参与者发生 NAFLD 的风险比（95% 置信区间）分别为 1.353 (1.100-1.663)、1.482 (1.207-1.820)、2.232 (1.832-2.720) 和 2.543 (2.082-3.106) apoB 水平分别在五分位数 2-5 中。在调整年龄、性别、体重指数和代谢综合征相关变量后，风险比有所减弱，但仍具有统计学显着性。结论：血清 apoB 水平升高独立预测发生 NAFLD 的风险增加。
Background & Aims: Cross-sectional studies have shown that apolipoprotein B (apoB) is positively associated with the prevalence of non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the prospective relationship between the serum apoB levels and the development of NAFLD in a Chinese population.Methods: A cohort of 7077 initially NAFLD-free participants was enrolled in this prospectively study. The incidence of NAFLD was calculated among participants with different baseline serum apoB quintiles. Cox proportional hazards regression analyses were conducted to calculate the risks for incident NAFLD.Results: During 41 555 person-year follow-ups, 1139 incident NAFLD cases were identified. The baseline apoB levels were linear and positively correlated with NAFLD incidence. The incidence was 16.99, 22.63, 24.73, 37.51 and 42.77 per 1000 person-year follow-up for participants with baseline apoB levels in quintiles 1-5, respectively. Compared with participants with baseline apoB levels in quintile 1, the hazard ratios (95% confidence interval) for incident NAFLD were 1.353 (1.100-1.663), 1.482 (1.207-1.820), 2.232 (1.832-2.720) and 2.543 (2.082-3.106) for participants with baseline apoB levels in quintile 2-5, respectively. The hazard ratios were attenuated but remained statistically significant after adjusting for age, gender, body mass index and variables associated with metabolic syndrome.Conclusion: Elevated serum apoB levels independently predict an increased risk for incident NAFLD.