Virulence and transmission success of the malarial parasite Plasmodium falciparum
Virulence and transmission success of the malarial parasite Plasmodium falciparum
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DOI：
10.1073/pnas.96.8.4563
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发表时间：
1999-04-13
影响因子：
11.1
通讯作者：
Day, KP
中科院分区：
文献类型：
--
作者：
Hayward, RE;Tiwari, B;Day, KP
恶性疟原虫的毒力与由var基因家族编码的命名为PfEMP 1（恶性疟原虫红细胞膜蛋白1）的变体表面抗原的表达相关。提供的数据显示恶性疟原虫的传播阶段也表达PfEMP 1变体。在这个宿主-寄生虫系统中的毒力可以被认为是从致病无性阶段的群体中优化性传播阶段的生产的可变结果。对PfEMP 1的免疫将有助于通过控制具有产生成熟传播阶段潜力的寄生虫种群来调节这种权衡。
Virulence of Plasmodium falciparum is associated with the expression of variant surface antigens designated PfEMP1 (P. falciparum erythrocyte membrane protein 1) that are encoded by a family of var genes. Data presented show that the transmission stages of P. falciparum also express PfEMP1 variants. Virulence in this host-parasite system can be considered a variable outcome of optimizing the production of sexual transmission stages from the population of disease-inducing asexual stages. Immunity to PfEMP1 will contribute to the regulation of this trade-off by controlling the parasite population with potential to produce mature transmission stages.