Agreement among 3 optical imaging methods for the assessment of optic disc topography
Agreement among 3 optical imaging methods for the assessment of optic disc topography
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DOI：
10.1016/j.ophtha.2005.07.003
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发表时间：
2005-12-01
期刊：
影响因子：
13.7
通讯作者：
Weinreb, RN
中科院分区：
文献类型：
--
作者：
Hoffmann, EM;Bowd, C;Weinreb, RN
目的：评估海德堡视网膜断层扫描仪（HRT II）、视网膜厚度分析仪（RTA）和光学相干断层扫描仪（StratusOCT）之间的椎间盘地形测量结果的一致性。设计：观察性横断面研究。参与者：42名受试者的42只随机选择的眼睛。每例受试者均接受HRT II、RTA和StratusOCT检查。两位经验丰富的检查员绘制了HRT II和RTA的轮廓线。Bland和Altman图用于评价仪器之间每个地形参数的一致性。评价每个地形参数的等级相关的斯皮尔曼系数。主要结果测量：通过基于回归的95%一致性限度评价，3种成像仪器之间的视盘地形测量的一致性。对于视盘面积，HRT II-RTA和StratusOCT-RTA之间的一致性显示存在比例偏倚，由回归线的显著斜率表示（分别为P = 0.01和P = 0.02）。仪器之间95%的一致性限度随实际视盘大小测量而变化。海德堡视网膜断层扫描仪椎间盘面积测量值往往始终低于StratusOCT椎间盘面积测量值（固定偏倚）。仪器之间的斯皮尔曼相关系数范围从r = 0.35（边缘面积，HRT II-StratusOCT）到r = 0.91（杯面积，HRT II-RTA）。然而，对一致性的分析表明，各项文书之间存在重大差异。因此，这些仪器不应互换使用，以获得青光眼诊断的视盘测量值。
Purpose: To assess the agreement of disc topography measurements between the Heidelberg Retina Tomograph (HRT II), Retinal Thickness Analyzer (RTA), and Optical Coherence Tomograph (StratusOCT).Design: Observational cross-sectional study.Participants: Forty-two randomly chosen eyes of 42 subjects.Methods. Each subject underwent HRT II, RTA, and StratusOCT examination. Two experienced examiners drew the contour lines for the HRT II and RTA. Bland and Altman plots were used to evaluate agreement for each topographic parameter among the instruments. The Spearman coefficient of rank correlation was evaluated for each topographic parameter.Main Outcome Measures: Agreement in the measurement of optic disc topography among 3 imaging instruments, as evaluated by regression-based 95% limits of agreement.Results: For optic disc area, the agreement between HRT II-RTA and StratusOCT-RTA revealed the existence of proportional bias, indicated by significant slopes of the regression lines (P = 0.01 and P = 0.02, respectively). The 95% limits of agreement between instruments varied with the actual optic disc size measurement. Heidelberg Retina Tomograph disc area measurements tended to be consistently lower than StratusOCT disc area measurements (fixed bias). The Spearman correlation coefficient between the instruments ranged from r = 0.35 (rim area, HRT II-StratusOCT) to r = 0.91 (cup area, HRT II-RTA).Conclusions: Moderate to high correlation was found in measurements of optic disc topography among different instruments. However, the analysis of agreement indicated important discrepancies among instruments. Therefore, these instruments should not be used interchangeably to obtain measurements of the optic disc for glaucoma diagnosis.