Pursuit and saccadic eye movement subregions in human frontal eye field: A high-resolution fMRI investigation
Pursuit and saccadic eye movement subregions in human frontal eye field: A high-resolution fMRI investigation
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DOI：
10.1093/cercor/12.2.107
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发表时间：
2002-02-01
期刊：
影响因子：
3.7
通讯作者：
Sweeney, JA
中科院分区：
文献类型：
--
作者：
Rosano, C;Krisky, CM;Sweeney, JA
最近的正电子发射断层扫描（PET）和功能性磁共振成像（fMRI）的研究，在人类的额叶眼场（FEF）定位到中央前沟（PCS）。在猕猴中，低阈值微刺激和单单位记录的研究已经找到了一个扫视子区域的FEF在一个有限的区域沿着前壁的弓形沟和追求子区域位于更深的沟接近眼底。这两个FEF亚区的功能组织和解剖位置在人类中仍有待确定。在本研究中，我们使用功能磁共振成像与高空间分辨率图像采集在3.0特斯拉映射扫视和追求相关领域的FEF内的两个墙壁的PCS在11个科目。我们将扫视相关区域定位于中央前沟前壁的上部，将追踪相关区域定位于沿着前壁的更深区域，在某些受试者中延伸至眼底或深后壁。这些研究结果本地化不同的追求和扫视亚区的FEF在人类和猕猴的这些FEF亚区的组织表现出高度的同源性。
Recent positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) studies in humans have localized the frontal eye field (FEF) to the precentral sulcus (PCS). In macaque monkeys, low-threshold microstimulation and single unit recording studies have located a saccadic subregion of FEF in a restricted area along the anterior wall of the arcuate sulcus and a pursuit subregion located deeper in the sulcus close to the fundus. The functional organization and anatomical location of these two FEF subregions are still to be defined in humans. In the present study, we used fMRI with high spatial resolution image acquisition at 3.0 Tesla to map the saccadeand pursuit-related areas of FEF within the two walls of the PCS in 11 subjects. We localized the saccade-related area to the upper portion of the anterior wall of the precentral sulcus and the pursuit-related area to a deeper region along the anterior wall, extending in some subjects to the fundus or deep posterior wall. These findings localize distinct pursuit and saccadic subregions of FEF in humans and demonstrate a high degree of homology in the organization of these FEF subregions in the human and the macaque monkey.