Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside.
Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside.
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DOI：
10.1172/jci170499
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发表时间：
2023-09-01
影响因子：
15.9
通讯作者：
Thomas, Paul G.
中科院分区：
文献类型：
--
作者：
Ghonim, Mohamed A.;Boyd, David F.;Flerlage, Tim;Thomas, Paul G.
近年来，人们对成纤维细胞如何在疾病状态下启动、维持和解决炎症产生了浓厚的兴趣。成纤维细胞包含具有不同功能的异质子集。这些群体的表型根据其在组织内的空间分布和导致疾病进展的免疫病理学线索而变化。除了在结构支持器官和重塑组织方面的作用外，成纤维细胞还介导与多种免疫细胞的关键相互作用。这些相互作用对于定义疾病机制和确定潜在的治疗靶点具有重要意义。尤其是呼吸道中的成纤维细胞，决定了许多急性和慢性肺部疾病的严重程度和结果，包括哮喘、慢性阻塞性肺病、急性呼吸窘迫综合征和特发性肺纤维化。在这里，我们回顾了最近的研究，这些研究定义了肺源性成纤维细胞的时空特性以及这些子集调节对损伤暴露的免疫反应的机制，并强调了与急性和慢性人类呼吸道疾病背景下的成纤维细胞生物学相关的过去、当前和未来的治疗目标。这一观点强调了组织环境在定义成纤维细胞免疫串扰中的重要性，并为确定有利于急性和慢性肺部疾病患者的治疗方法铺平了道路。
In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain, and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets with diverse functionality. The phenotypes of these populations vary depending on their spatial distribution within the tissue and the immunopathologic cues contributing to disease progression. In addition to their roles in structurally supporting organs and remodeling tissue, fibroblasts mediate critical interactions with diverse immune cells. These interactions have important implications for defining mechanisms of disease and identifying potential therapeutic targets. Fibroblasts in the respiratory tract, in particular, determine the severity and outcome of numerous acute and chronic lung diseases, including asthma, chronic obstructive pulmonary disease, acute respiratory distress syndrome, and idiopathic pulmonary fibrosis. Here, we review recent studies defining the spatiotemporal identity of the lung-derived fibroblasts and the mechanisms by which these subsets regulate immune responses to insult exposures and highlight past, current, and future therapeutic targets with relevance to fibroblast biology in the context of acute and chronic human respiratory diseases. This perspective highlights the importance of tissue context in defining fibroblast-immune crosstalk and paves the way for identifying therapeutic approaches to benefit patients with acute and chronic pulmonary disorders.
影响因子：
4.1
作者：
Bajbouj K;Hachim MY;Ramakrishnan RK;Fazel H;Mustafa J;Alzaghari S;Eladl M;Shafarin J;Olivenstein R;Hamid Q
通讯作者：
Hamid Q
影响因子：
15.1
作者：
Castro M;Kerwin E;Miller D;Pedinoff A;Sher L;Cardenas P;Knorr B;Lawrence D;Ossa D;Wang W;Maspero JF
通讯作者：
Maspero JF