Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice.
Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice.
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DOI：
10.1016/j.jep.2016.01.013
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发表时间：
2016-03-02
影响因子：
5.4
通讯作者：
Soumyanath A
中科院分区：
文献类型：
--
作者：
Gray NE;Harris CJ;Quinn JF;Soumyanath A
本研究探讨了阿育吠陀和传统中药中广泛使用的积雪草的认知增强作用。本研究的目的是确定药用植物积雪草水提物(CAW)对认知能力以及体内线粒体和抗氧化反应途径的影响。老年和幼龄C57BL/6小鼠饮水中加入CAW(2 mg/m L)。用Morris水迷宫(MWM)检测大鼠的学习记忆能力，收集组织标本，进行基因表达分析。CAW改善了老年动物的MWM表现，对幼年动物的表现影响不大。CAW还增加了幼年和老年动物大脑和肝脏中线粒体和抗氧化反应基因的表达。CAW处理组动物的海马区和额叶皮质突触标志物的表达也增加，但在小脑中未见表达。这些数据表明，CAW对健康小鼠的认知能力有增强作用。CAW引起的基因表达变化可能对线粒体的生物发生有影响，与抗氧化反应基因的激活一起可能有助于认知能力的改善。
This study investigates the cognitive enhancing effects of the plant Centella asiatica which is widely used Ayurvedic and traditional Chinese medicine. The goal of this study was to determine the effects of a water extract of the medicinal plant Centella asiatica (CAW) on cognitive ability as well as mitochondrial and antioxidant response pathways in vivo. Old and young C57BL/6 mice were treated with CAW (2mg/mL) in their drinking water. Learning and memory was assessed using Morris Water Maze (MWM) and then tissue was collected and gene expression analyzed. CAW improved performance in the MWM in aged animals and had a modest effect on the performance of young animals. CAW also increased the expression of mitochondrial and antioxidant response genes in the brain and liver of both young and old animals. Expression of synaptic markers was also increased in the hippocampus and frontal cortex, but not in the cerebellum of CAW-treated animals. These data indicate a cognitive enhancing effect of CAW in healthy mice. The gene expression changes caused by CAW suggest a possible effect on mitochondrial biogenesis, which in conjunction with activation of antioxidant response genes could contribute to cognitive improvement.