Findings of Thyroid Ultrasound Examination Within 3 Years After the Fukushima Nuclear Power Plant Accident: The Fukushima Health Management Survey
Findings of Thyroid Ultrasound Examination Within 3 Years After the Fukushima Nuclear Power Plant Accident: The Fukushima Health Management Survey
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DOI：
10.1210/jc.2017-01603
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发表时间：
2018-03-01
影响因子：
5.8
通讯作者：
Ohto, Hitoshi
中科院分区：
文献类型：
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作者：
Shimura, Hiroki;Sobue, Tomotaka;Ohto, Hitoshi
背景：福岛核电站事故后，儿童甲状腺癌受到高度关注。儿童甲状腺超声检查 (TUE) 的基线分析数据对于未来的研究非常重要。 目的：我们分析了福岛健康管理调查 (FHMS) 中儿童和青少年 TUE 调查结果的年龄和性别分布。 设计、设置和参与者：从 2011 年 10 月到 2014 年 3 月，地震发生时年龄不超过 18 岁的 294,905 名参与者在第一轮自愿接受了 TUE。 FHMS。对 2032 名受试者进行了二次确认检查。分析了甲状腺囊肿、结节和癌症的年龄和性别依赖性患病率和大小。主要结果指标：分析了结果的年龄、性别和大小分布。结果：分别在 68,009、1415 和 38 名男性受试者以及 73,014、2455 和 74 名女性受试者中检测到甲状腺囊肿、结节和细胞学疑似癌症。甲状腺结节和癌症的检出率随着年龄的增长而增加，但囊肿的检出率在 11 至 12 岁时达到峰值。性别影响青春期后甲状腺结节和甲状腺癌的患病率，但甲状腺囊肿的患病率差异较小。结论：福岛县甲状腺癌检出率明确，甲状腺结节和囊肿的个体比例随年龄差异较大。这项研究的结果将有助于未来儿童和青少年结节性甲状腺疾病的流行病学研究。
Context: Childhood thyroid cancer is of great concern after the Fukushima nuclear power plant accident. Baseline analytical data on thyroid ultrasound examination (TUE) in children are important for future studies.Objective: We analyzed the age and sex distribution of findings from the TUEs of children and adolescents in the Fukushima Health Management Survey (FHMS).Design, Setting, and Participants: From October 2011 through March 2014, 294,905 participants aged 18 years or younger at the time of the earthquake voluntarily had TUEs in the first round of the FHMS. A secondary confirmatory examination was performed in 2032 subjects. Age-and sexdependent prevalence and size of thyroid cysts, nodules, and cancers were analyzed.Main Outcome Measures: Age, sex, and size distribution of findings were analyzed.Results: Thyroid cysts, nodules, and cytologically suspected cancers were detected in 68,009, 1415, and 38 male subjects and in 73,014, 2455, and 74 female subjects, respectively. There was an agedependent increase in the detection rate of thyroid nodules and cancer, but that of cysts reached a peak at 11 to 12 years. Sex affected the prevalence of thyroid nodules and cancers after the onset of puberty, but only a small difference was exhibited in that of cysts.Conclusions: The thyroid cancer detection rate in Fukushima was clarified, and the proportion of individuals with thyroid nodules and cysts varied substantially by age. The results of this study will contribute to future epidemiological research on nodular thyroid diseases in children and adolescents.