CLINICOPATHOLOGICAL FEATURES OF MALIGNANT-LYMPHOMAS IN 294 HONG-KONG CHINESE PATIENTS, RETROSPECTIVE STUDY COVERING AN 8-YEAR PERIOD
CLINICOPATHOLOGICAL FEATURES OF MALIGNANT-LYMPHOMAS IN 294 HONG-KONG CHINESE PATIENTS, RETROSPECTIVE STUDY COVERING AN 8-YEAR PERIOD
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DOI：
10.1002/ijc.2910340202
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发表时间：
1984-01-01
影响因子：
6.4
通讯作者：
KHOO, RKK
中科院分区：
文献类型：
--
作者：
HO, FCS;TODD, D;KHOO, RKK
本文分析了294例成人恶性淋巴瘤的临床资料和组织学资料。这些患者于1975年至1982年8年间首次在香港玛丽医院就诊。27例患者（9.2%）患有霍奇金病（HD），267例患者患有非霍奇金淋巴瘤（NHL）。HD患者就诊时的中位年龄更小（45岁），男性：女性比例（2：1）高于NHL患者的相应数字（51岁和1.4：1）。在76例患者（28.5%的NHL）中，认为疾病起源于结外部位，其中48例为胃肠道淋巴瘤。根据Rappaport和基尔分类以及美国国家癌症研究所研究提出的工作公式（WF），可以对234例NHL进行重新分类;对于HD，在有合适材料的情况下，在26例病例中使用Rye分类。结节性/滤泡性淋巴瘤占结内NHL的17.1%，占结外NHL的5.3%。“组织细胞”（Rappaport）或大细胞（WF）亚型是弥漫性NHL中最常见的。只有四个伯基特淋巴瘤病例。对于HD，结节硬化亚型在女性中最常见（5/8例），而在男性中最常见的是混合细胞（10/18例）。64.7%的淋巴结NHL患者表现为IV期疾病。对于HD，II期和IV期疾病患者的数量大致相等（分别为10例和9例）。霍奇金病和滤泡性淋巴瘤的低发病率与日本等其他“东方”国家的数字相当。
The clinical records and histological material from 294 adult Chinese patients with malignant lymphoma were examined. These patients were first seen at the Queen Mary Hospital, Hong Kong, during the 8‐year period 1975‐82. There were 27 patients (9.2%) with Hodgkin's disease (HD) and 267 with non‐Hodgkin's lymphoma (NHL). The median age at presentation was younger for HD (45 years) and the male: female ratio was higher (2:1) than the corresponding figures for NHL of 51 years and 1.4:1. In 76 patients (28.5% of NHL), the disease was thought to have originated in an extra‐nodal site, 48 of these cases being gastrointestinal lymphomas. It was possible to reclassify 234 NHL according to the Rappaport and Kiel classifications, and the Working Formulation (WF) proposed by the US National Cancer Institute Study; for HD, the Rye classification was used in 26 cases where suitable material was available. Nodular/follicular lymphomas made up 17.1 % of nodal NHL and 5.3% of extra‐nodal NHL The “histiocytic” (Rappaport) or large‐cell (WF) subtype was the commonest amongst diffuse NHL. There were only four cases of Burkitt's lymphoma. For HD, the nodular sclerosing subtype was commonest in females (5 out of 8 cases) and for males, the commonest was mixed cellularity (10 out of 18 cases). Of patients with nodal NHL 64.7%, presented with Stage IV disease. For HD, there were about equal numbers of patients presenting with Stage II and Stage IV disease (10 and 9 respectively). The low incidence of Hodgkin's disease and of follicular lymphomas is comparable to figures from other “oriental” countries such as Japan.