Emerging regulation and functions of autophagy.

Emerging regulation and functions of autophagy.
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DOI:
10.1038/ncb2788
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发表时间:
2013-07
影响因子:
21.3
通讯作者:
Codogno P
Codogno P
中科院分区:
生物学1区
文献类型:
--
作者:
Boya P;Reggiori F;Codogno P

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自噬通过降解维持细胞、组织和生物体的稳态。Codogno, Boya和Reggiori回顾了最近的数据,发现了自噬的意想不到的功能,如代谢调节,膜运输和宿主防御调节。自噬通过降解维持细胞、组织和生物体的稳态。Atg(自噬相关)蛋白的复杂翻译后调节为与其他细胞过程的串扰增加了额外的入口点,并有助于定义细胞类型特异性的自噬调节。除了简单地认为这是一个专门致力于细胞成分更新的过程之外,最近的数据揭示了自噬和自噬相关基因的意想不到的功能,如代谢调节、膜运输和宿主防御调节,这表明了新的前沿领域。
Autophagy maintains cell, tissue and organism homeostasis through degradation. Codogno, Boya and Reggiori review recent data that have uncovered unexpected functions of autophagy, such as regulation of metabolism, membrane transport and modulation of host defenses. Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses — indicating the novel frontiers lying ahead.
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