Skeletal muscle (dys)function in heart failure with preserved ejection fraction.
Skeletal muscle (dys)function in heart failure with preserved ejection fraction.
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DOI：
10.1097/hco.0000000000000824
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发表时间：
2021-03-01
影响因子：
2.3
通讯作者：
Sam F
中科院分区：
文献类型：
--
作者：
Saw EL;Ramachandran S;Valero-Muñoz M;Sam F
骨骼肌功能障碍导致运动不耐受，表现为射血分数保留性心力衰竭（HFpEF）患者的呼吸困难和疲劳。本文就HFpEF中骨骼肌功能障碍的研究进展作一综述。HFpEF的动物和人类研究提供了骨骼肌结构和功能的病理生理学改变的见解，并已确定了几种分子机制。运动训练和靶向骨骼肌的新型药物疗法被提议作为治疗HFpEF的治疗干预措施。有证据表明骨骼肌功能障碍在HFpEF中发挥着病理生理作用。然而，需要精确的机制见解来理解HFpEF中骨骼肌功能的贡献。
Skeletal muscle dysfunction contributes to exercise intolerance, which manifests as dyspnea and fatiguability in patients with heart failure with preserved ejection fraction (HFpEF). This review aims to summarize the current understanding of skeletal muscle dysfunction in HFpEF. Animal and human studies on HFpEF provide insights into the pathophysiological alterations in skeletal muscle structure and function and several molecular mechanisms have been identified. Exercise training and novel pharmacological therapies that target skeletal muscle are proposed as therapeutic interventions to treat HFpEF. There is evidence that skeletal muscle dysfunction plays a pathophysiological role in HFpEF. However, precise mechanistic insights are needed to understand the contribution of skeletal muscle function in HFpEF.