Large-scale brain organization during facial emotion processing as a function of early life trauma among adolescent girls
Large-scale brain organization during facial emotion processing as a function of early life trauma among adolescent girls
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DOI：
10.1016/j.nicl.2017.12.001
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发表时间：
2018-01-01
影响因子：
4.2
通讯作者：
Kilts, Clinton D.
中科院分区：
文献类型：
--
作者：
Cisler, Josh M.;Privratsky, Anthony;Kilts, Clinton D.
背景：大量研究表明，早期生活创伤暴露对面部情绪加工过程中脑功能激活的影响，并经常表现出杏仁核过度活动和杏仁核与内侧PFC(MPFC)之间连接减弱。将这些特定于节点的发现与更大规模的脑组织网络模型联系起来的研究明显有限。方法：为了解决这些差距，我们应用图论分析了88名青春期女孩(n=59，遭受直接身体或性侵犯；n=29，健康对照)在fMRI期间的面部情绪处理任务中收集的fMRI数据。结果：在整个样本中，较严重的早期生活创伤与所有刺激类别的网络组织更模块化和分类，但整体效率较低。在被攻击的女孩中，早期生活创伤的严重程度和创伤后应激障碍的诊断都与模块化大脑组织的增加同时相关。我们还发现，更模块化的网络组织与杏仁核过度激活和杏仁核与内侧PFC之间的连接减弱有关。结论：这些结果表明，早期生活创伤与面部情绪加工过程中脑组织的增强有关，这种脑组织模式可能解释了儿童创伤与杏仁核过度活动和与mPFC连接减弱之间的常见联系。讨论了这些结果对神经回路模型的影响。
Background: A wealth of research has investigated the impact of early life trauma exposure on functional brain activation during facial emotion processing and has often demonstrated amygdala hyperactivity and weakened connectivity between amygdala and medial PFC (mPFC). There have been notably limited investigations linking these previous node-specific findings into larger-scale network models of brain organization.Method: To address these gaps, we applied graph theoretical analyses to fMRI data collected during a facial emotion processing task among 88 adolescent girls (n = 59 exposed to direct physical or sexual assault; n = 29 healthy controls), aged 11-17, during fMRI. Large-scale organization indices of modularity, assortativity, and global efficiency were calculated for stimulus-specific functional connectivity using an 883 region-of-interest parcellation.Results: Among the entire sample, more severe early life trauma was associated with more modular and assortative, but less globally efficient, network organization across all stimulus categories. Among the assaulted girls, severity of early life trauma and PTSD diagnoses were both simultaneously related to increased modular brain organization. We also found that more modularized network organization was related both to amygdala hyperactivation and weakened connectivity between amygdala and medial PFC.Conclusions: These results demonstrate that early life trauma is associated with enhanced brain organization during facial emotion processing and that this pattern of brain organization might explain the commonly observed association between childhood trauma and amygdala hyperactivity and weakened connectivity with mPFC. Implications of these results for neurocircuitry models are discussed.