Psychosis, behavioral disturbance, and the use of neuroleptics in dementia.
Psychosis, behavioral disturbance, and the use of neuroleptics in dementia.
复制标题
精神病、行为障碍以及精神安定药在痴呆症中的使用。
DOI：
10.1016/0010-440x(88)90020-x
复制
发表时间：
1988
影响因子：
7.3
通讯作者：
Mayeux,R
中科院分区：
文献类型：
--
作者：
Devanand,DP;Sackeim,HA;Mayeux,R
尽管精神药物在痴呆患者中的广泛使用，但很少有关于需要这种治疗的精神障碍和行为综合征的性质和患病率以及这种治疗的结果的研究。作者提出了策略，以克服固有的困难，试图获得痴呆症患者的症状特征。没有足够的证据支持使用精神抑制剂治疗怀疑、幻觉、失眠、激动、情绪责任和攻击性等症状;没有任何一种精神抑制剂可以被认为上级其他任何一种。很少有研究评估抗精神病药物对日常生活活动（ADL）的影响，也没有研究使用详细的神经心理学评估来检查它们对痴呆症认知功能的影响。
Despite the widespread use of psychotropic agents in patients with dementia, there is little available research on the nature and prevalence of psychiatric disturbance and behavioral syndromes requiring this treatment, and the results of such therapy. The authors suggest strategies to overcome difficulties inherent in attempting to obtain symptom profiles in demented patients. There is weak evidence to support the use of neuroleptics in the treatment of symptoms like suspiciousness, hallucinations, sleeplessness, agitation, emotional liability, and aggressiveness; no individual neuroleptic can be considered superior to any other for this purpose. Few studies have evaluated the effect of neuroleptics on activities of daily life (ADL), and no study has used detailed neurophsychological evaluation to examine their effects on cognitive function in dementia.