Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes
Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes
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DOI：
10.1007/s00125-005-1806-3
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发表时间：
2005-07-01
期刊：
影响因子：
8.2
通讯作者：
Kadowaki, T
中科院分区：
文献类型：
--
作者：
Hara, K;Horikoshi, M;Kadowaki, T
目的/假设：脂联素由脂肪细胞分泌，是一种抗糖尿病和抗动脉粥样硬化的脂肪因子。我们最近克隆了编码两种脂联素受体（ADIPOR 1和ADIPOR 2）的基因。本研究的目的是检查ADIPOR 1和/或ADIPOR 2是否在日本人群中胰岛素抵抗或2型糖尿病的遗传易感性中起主要作用。研究方法：通过直接测序和公共数据库检索，我们确定了ADIPOR 1和ADIPOR 2的单核苷酸多态性（SNP），并调查这些SNP是否与日本人群的胰岛素抵抗和2型糖尿病相关。结果如下：ADIPOR 1染色体区域的连锁不平衡（LD）几乎完全保留，而ADIPOR 2的LD保存得不太好。ADIPOR 1或ADIPOR 2中的SNPs与胰岛素抵抗或2型糖尿病无显著相关。在2型糖尿病和非糖尿病受试者之间没有观察到ADIPOR 1或ADIPOR 2单倍型频率的差异。结论/解释：ADIPOR 1或ADIPOR 2的遗传变异不太可能导致日本人群中胰岛素抵抗或2型糖尿病的常见遗传易感性。
Aims/hypothesis: Secreted by adipocytes, adiponectin is a hormone that acts as an antidiabetic and anti-atherogenic adipokine. We recently cloned the genes encoding two adiponectin receptors (ADIPOR1 and ADIPOR2). The aim of this study was to examine whether ADIPOR1 and/or ADIPOR2 play a major role in genetic susceptibility to insulin resistance or type 2 diabetes in the Japanese population. Methods: By direct sequencing and a search of public databases, we identified single nucleotide polymorphisms (SNPs) in ADIPOR1 and ADIPOR2, and investigated whether these SNPs are associated with insulin resistance and type 2 diabetes in the Japanese population. Results: The linkage disequilibrium (LD) in the chromosomal region of ADIPOR1 was almost completely preserved, whereas the LD in ADIPOR2 was less well preserved. None of the SNPs in ADIPOR1 or ADIPOR2 were significantly associated with insulin resistance or type 2 diabetes. No differences in ADIPOR1 or ADIPOR2 haplotype frequencies were observed between type 2 diabetic and non-diabetic subjects. Conclusions/interpretation: Genetic variations in ADIPOR1 or ADIPOR2 are unlikely to lead to a common genetic predisposition to insulin resistance or type 2 diabetes in the Japanese population.