Astragalus polysaccharides combined with ibuprofen exhibit a therapeutic effect on septic rats via an anti-inflammatory cholinergic pathway
Astragalus polysaccharides combined with ibuprofen exhibit a therapeutic effect on septic rats via an anti-inflammatory cholinergic pathway
复制标题
DOI：
10.3892/etm.2017.4865
复制
发表时间：
2017-10-01
影响因子：
2.7
通讯作者：
Mo, Fei
中科院分区：
文献类型：
--
作者：
Liu, Li;Chen, Shibiao;Mo, Fei
本研究的目的是探讨黄芪多糖（APS）联合布洛芬（IBU）治疗脓毒症的效果及其潜在机制。在盲肠结扎穿刺（CLP）大鼠模型中评估联合药物治疗。测定肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6和乙酰胆碱（ACh）的血清浓度。还观察了肺组织中烟碱乙酰胆碱（nAChR）α7受体的表达和组织病理学变化。与未治疗的大鼠和仅用任一组分治疗的大鼠相比，联合治疗显着降低了 TNF-α 和 IL-6 的产生（P
The aim of the present study was to investigate the effects of Astragalus polysaccharides (APS) in combination with ibuprofen (IBU) in the treatment of sepsis and the underlying mechanism. The combined drug treatment was evaluated in a rat model of cecal ligation and puncture (CLP). The serum concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and acetylcholine (ACh) were determined. Nicotinic acetylcholine (nAChR) alpha 7 receptor expression and histopathological changes in the lung tissue were also observed. When compared with untreated rats and rats treated with either component alone, the combined treatment significantly decreased the production of TNF-alpha and IL-6 (P