Delivery of mRNA for regulating functions of immune cells.
Delivery of mRNA for regulating functions of immune cells.
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传递 mRNA 以调节免疫细胞的功能
DOI：
10.1016/j.jconrel.2022.03.033
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Shi J;Huang MW;Lu ZD;Du XJ;Shen S;Xu CF;Wang J
免疫细胞功能异常通常与多种疾病有关，包括癌症、自身免疫性疾病和传染病。基于信使核糖核酸(Messenger RNA，mRNA)的治疗可以调节免疫细胞的功能或赋予免疫细胞新的功能，从而产生治疗性免疫反应来治疗这些疾病。然而，mRNA在生理环境中是不稳定的，很难进入靶细胞的细胞质，因此，有效的信使核糖核酸递送系统是发展信使核糖核酸治疗的关键。辉瑞公司的BioNTech和Modern na两种mRNA疫苗已经证明，脂质纳米粒(LNPs)可以将mRNA输送到树突状细胞(DC)中，诱导针对SARS冠状病毒2的免疫，这为mRNA治疗的发展打开了闸门。除树突状细胞外，其他免疫细胞也有望成为基因治疗的靶点。本文就信使核糖核酸传递障碍及其在调节不同免疫细胞功能方面的研究进展作一综述。通过信使核糖核酸来调节免疫细胞的功能，在预防或治疗各种疾病方面有着很大的希望。
Abnormal immune cell functions are commonly related to various diseases, including cancer, autoimmune diseases, and infectious diseases. Messenger RNA (mRNA)-based therapy can regulate the functions of immune cells or assign new functions to immune cells, thereby generating therapeutic immune responses to treat these diseases. However, mRNA is unstable in physiological environments and can hardly enter the cytoplasm of target cells; thus, effective mRNA delivery systems are critical for developing mRNA therapy. The two mRNA vaccines of Pfizer-BioNTech and Moderna have demonstrated that lipid nanoparticles (LNPs) can deliver mRNA into dendritic cells (DCs) to induce immunization against severe acute respiratory syndrome coronavirus 2, which opened the floodgates to the development of mRNA therapy. Apart from DCs, other immune cells are promising targets for mRNA therapy. This review summarized the barriers to mRNA delivery and advances in mRNA delivery for regulating the functions of different immune cells. Delivery of mRNA to regulate the functions of immune cells holds great promises in the prevention or treatment of various diseases.
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影响因子：
6.2
作者：
Caffrey, Leah M.;deRonde, Brittany M.;Minter, Lisa M.;Tew, Gregory N.
通讯作者：
Tew, Gregory N.
影响因子：
29.4
作者：
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DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
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通讯作者：
COVE Study Group
DOI：
10.1016/j.jconrel.2021.08.040
发表时间：
2021-11-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Parayath NN;Hao S;Stephan SB;Koehne AL;Watson CE;Stephan MT
通讯作者：
Stephan MT
影响因子：
6.6
作者：
Fan, Ya-Nan;Li, Min;Wang, Jun
通讯作者：
Wang, Jun