Effects of oral carbohydrate with amino acid solution on the metabolic status of patients in the preoperative period: a randomized, prospective clinical trial.
Effects of oral carbohydrate with amino acid solution on the metabolic status of patients in the preoperative period: a randomized, prospective clinical trial.
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DOI：
10.1007/s00540-016-2217-y
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发表时间：
2016-10
影响因子：
2.8
通讯作者：
Tsutsumi, Yasuo M.
中科院分区：
文献类型：
--
作者：
Tsutsumi, Rie;Kakuta, Nami;Kadota, Takako;Oyama, Takuro;Kume, Katsuyoshi;Hamaguchi, Eisuke;Niki, Noriko;Tanaka, Katsuya;Tsutsumi, Yasuo M.
关键词：
如今，手术后的恢复越来越需要，术前营养摄入可能有利于此目的。在这项研究中，我们研究了术前摄入含氨基酸的碳水化合物（ONS）溶液是否可以改善麻醉诱导前的饥饿状态和脂质代谢。这项随机、前瞻性临床试验纳入了24例患者，他们在全身麻醉下手术前被分为两组：对照组，包括手术前一天最后一餐后禁食的患者（仅允许喝水），以及ONS组，包括手术前2小时服用ONS溶液的患者。在麻醉开始时评估生化标志物、呼吸商和心身评分。与对照组相比，ONS组血清游离脂肪酸水平显著降低[对照组：828（729，1004）µEq/L，ONS组：479（408，610）µEq/L，P = 0.0002，中位数（第25，第75百分位数）]和总酮体[对照组：119（68，440）µmol/L，ONS组：40 [27，64] µmol/L，P = 0.037]。此外，使用视觉模拟量表进行的分析显示，对照组的焦虑、饥饿和口渴的术前评分较高，两组之间的任何其他主观幸福感指标均无差异。这项研究的结果表明，术前ONS摄入改善了麻醉诱导前的脂质代谢和饥饿状态。此外，与完全禁食相比，它可以提供更好的术前心理健康。
Enhanced recovery after surgery is increasingly desired nowadays, and preoperative nutrient intake may be beneficial for this purpose. In this study, we investigated whether the intake of preoperative carbohydrate with amino acid (ONS) solution can improve starvation status and lipid catabolism before the induction of anesthesia. This randomized, prospective clinical trial included 24 patients who were divided into two groups before surgery under general anesthesia: a control group, comprising patients who fasted after their last meal the day before surgery (permitted to drink only water), and an ONS group, comprising patients who consumed ONS solution 2 h before surgery. Biochemical markers, the respiratory quotient, and psychosomatic scores were assessed at the initiation of anesthesia. Compared with the control group, the ONS group showed significantly lower serum free fatty acid levels [control group: 828 (729, 1004) µEq/L, ONS group: 479 (408, 610) µEq/L, P = 0.0002, median (25th, 75th percentile)] and total ketone bodies [control group: 119 (68, 440) µmol/L, ONS group: 40 [27, 64] µmol/L, P = 0.037]. In addition, analysis using the Visual Analog Scale showed higher preoperative scores for anxiety, hunger, and thirst for the control group, with no differences in any other measure of subjective well-being between groups. The results of this study suggest that preoperative ONS intake improves lipid catabolism and starvation status before the induction of anesthesia. Furthermore, it can provide better preoperative mental health compared with complete fasting.
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影响因子：
2.1
作者：
Henriksen, MG;Hessov, I;Rodt, SÅ
通讯作者：
Rodt, SÅ
影响因子：
4.4
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影响因子：
6.3
作者：
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通讯作者：
Ljungqvist, O
影响因子：
6.3
作者：
Lobo, Dileep N.;Hendry, Paul O.;Fearon, Kenneth C. H.
通讯作者：
Fearon, Kenneth C. H.
影响因子：
6.3
作者：
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通讯作者：
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