Effects of MPC-1304, a novel calcium antagonist, on stroke-prone spontaneously hypertensive rats.
Effects of MPC-1304, a novel calcium antagonist, on stroke-prone spontaneously hypertensive rats.
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MPC-1304（一种新型钙拮抗剂）对易发生中风的自发性高血压大鼠的影响。
DOI：
10.1536/ihj.36.543
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发表时间：
1994
影响因子：
--
通讯作者：
K. Taniyama
中科院分区：
文献类型：
--
作者：
M. Niwa;K. Shigematsu;T. Maeda;M. Fujimoto;K. Yamashita;Y. Kataoka;K. Taniyama
研究了MPC-1304（一种新开发的1，4-二氢吡啶衍生物）对高盐饮食（0.8%NaCl）喂养的易卒中自发性高血压大鼠的血压和高血压并发症的影响。以尼卡地平降压疗效为对照。在整个实验期间（8至30周龄），将MPC-1304和尼卡地平分别以0.01%（0.01%MPC-1304饮食）、0.03%（0.03%MPC-1304饮食）和0.1%（0.1%尼卡地平饮食）的剂量添加到饮食中。这种MPC-1304和尼卡地平的长期摄入抑制了高血压的发展，并降低了血清中的血尿素氮、肌酐、甘油三酯和总胆固醇的浓度。用MPC-1304治疗抑制脑中风、心脏纤维化、增殖性和纤维素样小动脉炎和恶性肾硬化的发生。0.01%MPC-1304和0.1%尼卡地平饲料的降压效果无显著差异。因此，MPC-1304在易卒中的自发性高血压大鼠中具有抗高血压作用。
The effects of MPC-1304, a newly developed 1,4-dihydropyridine derivative, on blood pressure and hypertensive complications in stroke-prone spontaneously hypertensive rats fed a high-salt diet (0.8% NaCl), were investigated. The antihypertensive effectiveness of nicardipine was used for the purpose of comparison. MPC-1304 and nicardipine were added to the diet, in doses of 0.01% (0.01% MPC-1304 diet), 0.03% (0.03% MPC-1304 diet) and 0.1% (0.1% nicardipine diet), respectively, throughout the experimental period (8 to 30 weeks of age). This chronic ingestion of MPC-1304 and nicardipine inhibited the development of hypertension and reduced the concentration of blood urea nitrogen, creatinine, triglyceride and total cholesterol in serum. Treatment with MPC-1304 inhibited the incidence of cerebral stroke, cardiac fibrosis, proliferative and fibrinoid arteriolitis and malignant nephrosclerosis. There was no significant difference in the antihypertensive effectiveness between 0.01% MPC-1304 and 0.1% nicardipine diets. Thus, MPC-1304 had antihypertensive effects in stroke-prone spontaneously hypertensive rats.