Does Toll-like receptor 3 play a biological role in virus infections?
Does Toll-like receptor 3 play a biological role in virus infections?
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DOI：
10.1016/j.virol.2004.01.033
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发表时间：
2004-05-01
期刊：
影响因子：
3.7
通讯作者：
Oldstone, MBA
中科院分区：
文献类型：
--
作者：
Edelmann, KH;Richardson-Burns, S;Oldstone, MBA
Toll样受体（TLR）家族的功能是识别保守的微生物和病毒结构，目的是激活信号通路以激发针对这些生物体感染的免疫应答。例如，体外研究表明，TLR 3配体是一种双链RNA（dsRNA），是病毒感染的产物。根据这一观察，已经提出TLR 3可能是病毒感染的重要第一信号。我们通过研究TLR 3在四种不同的感染性病毒模型（淋巴细胞性脉络丛脑膜炎病毒（LCMV）、水泡性口炎病毒（VSV）、鼠巨细胞病毒（MCMV）和呼肠孤病毒）和TLR 3基因缺陷（（-/-））小鼠中的作用来探讨这一问题。我们的研究结果表明，TLR 3是不是普遍需要产生有效的抗病毒反应，因为TLR 3的缺乏不改变病毒的发病机制或损害主机的产生适应性抗病毒反应，这些病毒。(C)2004爱思唯尔公司All rights reserved.
The Toll-like receptor (TLR) family functions to recognize conserved microbial and viral structures with the purpose of activating signal pathways to instigate immune responses against infections by these organisms. For example, in vitro studies reveal that the TLR3 ligand is a double-stranded RNA (dsRNA), a product of viral infections. From this observation, it has been proposed that TLR3 is likely an important first signal for virus infections. We approached this issue by investigating the role of TLR3 in four different infectious viral models (lymphocytic choriomeningitis virus (LCMV), vesicular stomatitis virus (VSV), murine cytomegalovirus (MCMV), and reovirus) and in TLR3 genetically deficient ((-/-)) mice. Our results indicate that TLR3 is not universally required for the generation of effective antiviral responses because the absence of TLR3 does not alter either viral pathogenesis or impair host's generation of adaptive antiviral responses to these viruses. (C) 2004 Elsevier Inc. All rights reserved.