Attentional modulation of startle in psychosis-prone college students.
Attentional modulation of startle in psychosis-prone college students.
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DOI：
10.1111/j.1469-8986.1995.tb02955.x
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发表时间：
1995-05
期刊：
影响因子：
3.7
通讯作者：
A. Schell;Michael E. Dawson;E. Hazlett;D. Filion
中科院分区：
文献类型：
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作者：
A. Schell;Michael E. Dawson;E. Hazlett;D. Filion
本文研究了精神病高危大学生和正常对照者对惊吓眨眼的注意调节。处于危险中的受试者在快感缺乏或知觉偏差-神奇思维（每mags）量表上的得分都很高。受试者被呈现为被关注和被忽略的音调;在被关注和被忽略的音调开始后以及在音调间隔期间，以60、120、240或2,000 ms的导联间隔呈现白色噪声惊吓探针。对照组在120 ms时表现出更大的惊吓眨眼抑制作用，在2,000 ms时表现出更大的易化作用，表明注意力对前脉冲抑制和易化作用的调节。两个高危组的早期抑制和晚期易化的总体水平均正常。然而，per-mags未能显示注意力调制的抑制在120毫秒或促进在2,000毫秒;快感缺乏症显示没有调制的抑制和调制的促进延迟发展。结果为per-mags是惊人的相似，在精神分裂症患者中观察到的，并建议这些赤字指标的特质相关的脆弱性，精神分裂症的频谱。
Attentional modulation of startle eyeblink was studied in college students putatively at risk for psychosis and in normal controls. At-risk subjects had extreme scores on scales for either anhedonia or perceptual aberration-magical thinking (per-mags). Subjects were presented with to-be-attended and to-be-ignored tones; white noise startle probes were presented at lead intervals of 60, 120, 240, or 2,000 ms following the onset of attended and ignored tones and during intertone intervals. Controls showed greater inhibition of startle blink at 120 ms and greater facilitation at 2,000 ms during to-be-attended than to-be-ignored tone, demonstrating attentional modulation of prepulse inhibition and facilitation. Both at-risk groups showed normal overall levels of early inhibition and late facilitation. However, per-mags failed to show attentional modulation of either inhibition at 120 ms or facilitation at 2,000 ms; anhedonics showed no modulation of inhibition and modulation of facilitation was delayed in development. The results for the per-mags are strikingly similar to those observed in schizophrenic patients and suggest that these deficits index a trait-linked vulnerability to disorders in the schizophrenic spectrum.