Hepatitis B virus subgenotype F3 reactivation with vaccine escape mutations: A case report and review of the literature.
Hepatitis B virus subgenotype F3 reactivation with vaccine escape mutations: A case report and review of the literature.
复制标题
乙型肝炎病毒亚型F3用疫苗逃生突变重新激活：病例报告和文献综述。
DOI：
10.4254/wjh.v10.i7.509
复制
发表时间：
2018-07-27
影响因子：
2.4
通讯作者：
Spengler U
中科院分区：
文献类型：
--
作者：
Schlabe S;van Bremen K;Aldabbagh S;Glebe D;Bremer CM;Marsen T;Mellin W;Cristanziano VD;Eis-Hübinger AM;Spengler U
Hepatitis B represents a global health threat because its chronic course and sequelae contribute to a high morbidity and mortality. Hepatitis B virus (HBV) infection can be controlled by vaccines, antiviral treatment, and by interrupting transmission. Rare vaccine escape mutants are serious because they eliminate vaccine protection. Here, we present a 74-year-old vaccinated patient with HBV reactivation 11 years after kidney transplantation. The patient was HBV-positive but HBsAg-negative prior to vaccination 6 years before transplantation. The reactivated virus was HBV genotype F3 with vaccine escape mutations G145R, P120Q, and Q129P. The patient was successfully treated with entecavir. The epidemiological reasons for this subgenotype, which is extremely rare in Western Europe, were unclear. This case illustrates that second-generation vaccines are not always effective in a specific group of patients.
