Inhibition of ADP-induced P-selectin Expression and Platelet-Leukocyte Conjugate Formation by Clopidogrel and the P2Y12 Receptor Antagonist AR-C69931MX but not Aspirin
Inhibition of ADP-induced P-selectin Expression and Platelet-Leukocyte Conjugate Formation by Clopidogrel and the P2Y12 Receptor Antagonist AR-C69931MX but not Aspirin
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DOI：
10.1055/s-0037-1613242
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发表时间：
2002-09
影响因子：
6.7
通讯作者：
R. Storey;H. Judge;R. Wilcox;S. Heptinstall
中科院分区：
文献类型：
--
作者：
R. Storey;H. Judge;R. Wilcox;S. Heptinstall
血小板-白细胞相互作用被认为具有促炎作用，这在缺血性心脏病的病理生理学中可能很重要。氯吡格雷和新型静脉内抗血栓药物AR-C69931 MX在血小板P2 Y12受体水平起作用，已知P2 Y12受体可放大许多血小板激动剂诱导的血小板活化、聚集和其他反应。我们研究了氯吡格雷和阿司匹林对ADP诱导的健康志愿者血小板-白细胞结合物形成和P-选择素表达的影响。还评估了氯吡格雷和AR-C69931 MX对缺血性心脏病患者的作用。还在体外研究了AR-C69931 MX和阿司匹林。氯吡格雷和AR-C69931 MX抑制ADP诱导的血小板聚集、P-选择素表达和血小板-白细胞结合物形成，而阿司匹林没有抑制作用。氯吡格雷和AR-C69931 MX的这些作用可能在急性冠状动脉综合征的管理中提供治疗益处。
Summary Platelet-leukocyte interactions are recognised to have pro-inflammatory effects, which may be important in the pathophysiology of ischaemic heart disease. Clopidogrel and the novel intravenous antithrombotic agent AR-C69931MX act at the level of the platelet P2Y12 receptor, which is known to amplify platelet activation, aggregation and other responses induced by numerous platelet agonists. We studied the effects of clopidogrel and aspirin on ADP-induced platelet-leukocyte conjugate formation and P-selectin expression in healthy volunteers. The effects of clopidogrel and AR-C69931MX administered to patients with ischaemic heart disease were also assessed. AR-C69931MX and aspirin were also studied in vitro. Clopidogrel and AR-C69931MX suppressed ADP-induced platelet aggregation, P-selectin expression and platelet-leukocyte conjugate formation whereas aspirin had no inhibitory effect. These effects of clopidogrel and AR-C69931MX may confer therapeutic benefits in the management of acute coronary syndromes.