Clinical, pathological and immunological aspects of periodontal disease
Clinical, pathological and immunological aspects of periodontal disease
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DOI：
10.1080/000163501750266747
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发表时间：
2001-06-01
影响因子：
2
通讯作者：
Lappin, DF
中科院分区：
文献类型：
--
作者：
Kinane, DF;Lappin, DF
本文就牙周炎发生发展过程中的炎症和免疫反应进行综述。牙周炎的易感性可能与浆细胞是否在个体或部位的组织中占主导地位有关，以响应来自牙菌斑的微生物侵袭。个体或部位形成广泛的浆细胞浸润的趋势可能表明不能防御牙周致病细菌，因此易患牙周炎。选定的相关领域目前感兴趣的细胞和体液免疫被认为是在牙周的背景下。这些热点问题包括（a）免疫和炎症细胞归巢至靶组织;（B）免疫和炎症细胞的局部增殖和合成活性;（c）炎症和免疫细胞的细胞因子谱;和（d）局部产生的抗体的免疫球蛋白亚类。
The inflammatory and immune responses during the development and progression of periodontitis are reviewed. Susceptibility to periodontitis may be related to whether plasma cells predominate in the tissues of an individual, or a site, in response to the microbial insult from dental plaque. The tendency for an individual or site to form an extensive plasma cell infiltrate may indicate an inability to defend against periodontopathogenic bacteria and thus a predisposition to periodontitis. Selected pertinent areas of current interest in cellular and humoral immunology are considered within the periodontal context. These topical issues include (a) homing of immune and inflammatory cells to target tissues; (b) the local proliferation and synthetic activity of immune and inflammatory cells; (c) the cytokine profile of the inflammatory and immune cells; and (d) the immunoglobulin subclasses of locally produced antibodies.