Immediate thalamic sensory plasticity depends on corticothalamic feedback
Immediate thalamic sensory plasticity depends on corticothalamic feedback
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DOI：
10.1073/pnas.96.14.8200
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发表时间：
1999-07-06
影响因子：
11.1
通讯作者：
Nicolelis, MAL
中科院分区：
文献类型：
--
作者：
Krupa, DJ;Ghazanfar, AA;Nicolelis, MAL
同时获得多个神经元合奏录音从初级躯体感觉（SI）皮层和腹后内侧丘脑（VPM）之前和期间的SI皮层的可逆性失活和外周三叉神经纤维的可逆性皮下阻滞联合给药。这个程序进行量化的贡献下降corticofugal预测（i）丘脑体感感受野的正常组织和（ii）丘脑体感可塑性重组，立即遵循周边deafferentation。可逆失活的SI皮层导致整个VPM的感受野特性的立即变化。皮层失活也显着减少，但没有完全消除发生WM感受野重组所造成的可逆性外周去传入。这一结果表明，丘脑的可塑性，即看到后立即外周deafferentation是依赖于下行-corticofugal预测和上行trigeminothalamic预测。
Multiple neuron ensemble recordings were obtained simultaneously from both the primary somatosensory (SI) cortex and the ventroposterior medial thalamus (VPM) before and during the combined administration of reversible inactivation of the SI cortex and a reversible subcutaneous block of peripheral trigeminal nerve fibers. This procedure was performed to quantify the contribution of descending corticofugal projections on (i) the normal organization of thalamic somatosensory receptive fields and (ii) the thalamic somatosensory plastic reorganization that immediately follows a peripheral deafferentation. Reversible inactivation of SI cortex resulted in immediate changes in receptive field properties throughout the VPM. Cortical inactivation also significantly reduced but did not completely eliminate the occurrence of WM receptive field reorganization resulting from the reversible peripheral deafferentation. This result suggests that the thalamic plasticity that is seen immediately after a peripheral deafferentation is dependent upon both descending-corticofugal projections and ascending trigeminothalamic projections.