Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2.
Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2.
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DOI：
10.1038/s41598-021-94547-0
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发表时间：
2021-07-21
影响因子：
4.6
通讯作者：
Waggoner JJ
中科院分区：
文献类型：
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作者：
Levy JM;Frediani JK;Tyburski EA;Wood A;Figueroa J;Kempker RR;Rebolledo PA;Gonzalez MD;Sullivan J;Vos MB;O'Neal J;Martin GS;Lam WA;Waggoner JJ
重复样本采集对COVID-19检测性能的影响尚不清楚。FDA和CDC目前建议主要收集诊断样本，以尽量减少假阴性结果的感知风险。因此，我们在佐治亚州亚特兰大市接受COVID-19检测的325名有症状患者中评估了重复样本采集与检测性能之间的关联。在连续收集的中鼻甲样本与分子（n = 74，100%一致性）和基于抗原（n = 147，97%一致性，kappa = 0.95，CI = 0.88-1.00）诊断测定之间发现高度一致性。重复样本采集不会降低COVID-19检测性能，表明可以采集多个样本进行检测验证和临床诊断。
The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74, 100% concordance) and antigen-based (n = 147, 97% concordance, kappa = 0.95, CI = 0.88–1.00) diagnostic assays. Repeated sample collection does not decrease COVID-19 test performance, demonstrating that multiple samples can be collected for assay validation and clinical diagnosis.
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影响因子：
9.4
作者：
Callahan, Cody J.;Lee, Rose;Arnaout, Ramy A.
通讯作者：
Arnaout, Ramy A.
影响因子：
4.5
作者：
James AE;Gulley T;Kothari A;Holder K;Garner K;Patil N
通讯作者：
Patil N
影响因子：
19.7
作者：
Bernheim, Adam;Mei, Xueyan;Chung, Michael
通讯作者：
Chung, Michael
影响因子：
9.4
作者：
Binnicker MJ
通讯作者：
Binnicker MJ
DOI：
10.15585/mmwr.mm7003e3
发表时间：
2021-01-22
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Prince-Guerra JL;Almendares O;Nolen LD;Gunn JKL;Dale AP;Buono SA;Deutsch-Feldman M;Suppiah S;Hao L;Zeng Y;Stevens VA;Knipe K;Pompey J;Atherstone C;Bui DP;Powell T;Tamin A;Harcourt JL;Shewmaker PL;Medrzycki M;Wong P;Jain S;Tejada-Strop A;Rogers S;Emery B;Wang H;Petway M;Bohannon C;Folster JM;MacNeil A;Salerno R;Kuhnert-Tallman W;Tate JE;Thornburg NJ;Kirking HL;Sheiban K;Kudrna J;Cullen T;Komatsu KK;Villanueva JM;Rose DA;Neatherlin JC;Anderson M;Rota PA;Honein MA;Bower WA
通讯作者：
Bower WA