Clinical application of sonographic elasticity imaging for aging of deep venous thrombosis - Preliminary findings
Clinical application of sonographic elasticity imaging for aging of deep venous thrombosis - Preliminary findings
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DOI：
10.7863/jum.2003.22.5.443
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发表时间：
2003-05-01
影响因子：
2.3
通讯作者：
Emelianov, SY
中科院分区：
文献类型：
--
作者：
Rubin, JM;Aglyamov, SR;Emelianov, SY
Objective.老年下肢深静脉血栓形成是临床上的一个重要而又困难的问题。因为我们知道血栓在成熟时会变硬，我们已经初步测试了超声弹性成像，一种估计组织硬度的技术，以老化静脉血栓。方法.对2例下肢血栓的成人患者进行了研究。1例患者有临床慢性血栓（至少3年），而另1例患者的血栓为临床亚急性（25天）。我们进行徒手压缩超声扫描，使用5 MHz的线阵换能器相敏B扫描帧离线处理的二维复杂的相关性为基础的自适应斑点跟踪技术。分析了静脉壁、血栓和周围组织中内部应变的分布。将凝块硬度标准化为静脉壁。结果慢性凝块是均匀的，并且慢性凝块中的应变至少比血管壁中的应变小10倍。亚急性凝块的异质性要大得多，平均而言，凝块中的应变幅度是血管壁中应变幅度的3至4倍。结论.在这项初步工作中，2个血栓出现非常不同，这些结果表明，弹性成像可能能够老化深静脉血栓形成。
Objective. Aging of deep venous thrombosis is an important and difficult clinical problem. Because it is known that thrombi harden as they mature, we have preliminarily tested sonographic elasticity imaging, a technique that estimates tissue hardness, to age venous thrombi. Methods. Two adult patients with lower extremity thrombi were studied. One had a clinically chronic thrombus (at least 3 years old), whereas the other patient's thrombus was clinically subacute (25 days old). We performed freehand compression sonographic scans using a 5-MHz linear array transducer Phase-sensitive B-scan frames were processed offline by a two-dimensional complex correlation-based adaptive speckle-tracking technique. The distribution of internal strains in the wall of the vein, thrombus, and surrounding tissue was analyzed. Clot hardness was normalized to the venous wall. Results. The chronic clot was homogeneous, and the strain in the chronic clot was at least 10 times smaller than that in the vessel wall. The subacute clot was much more heterogeneous, and, on average, the strain magnitude in the clot was 3 to 4 times greater than that in the vessel wall. Conclusions. In this preliminary work, the 2 thrombi appeared very different, and these results suggest that elasticity imaging may be able to age deep venous thrombosis.