Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats.
Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats.
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DOI：
10.1186/1476-511x-12-8
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发表时间：
2013-02-04
影响因子：
4.5
通讯作者：
Yanagita T
中科院分区：
文献类型：
--
作者：
Nagao K;Jinnouchi T;Kai S;Yanagita T
白藜芦醇(反式-3，4‘，5-三羟基二苯乙烯)是植物在各种逆境下产生的一种天然植物防御素。多项研究表明，白藜芦醇存在于各种人类饮食中，包括葡萄酒、葡萄、浆果和花生，它具有多种有益的健康特性，如抗动脉粥样硬化、抗肥胖、抗癌、抗炎和抗氧化活性。在这项研究中，我们评估了白藜芦醇对肥胖发病机制和非高脂饮食肥胖OLETF大鼠营养物质代谢的影响。白藜芦醇饲料喂养OLETF大鼠4周后，虽然血清和肝脏中的脂质参数没有改变，但明显阻止了腹部白色脂肪组织的蓄积。呼吸气体分析结果表明，饮食白藜芦醇可部分促进OLETF大鼠1周和3周的脂肪代谢，减少碳水化合物和蛋白质的摄入。此外，饲喂白藜芦醇的OLETF大鼠4周后，肉碱棕榈酰转移酶的脂肪mRNA水平高于对照组。我们的研究表明，饮食中的白藜芦醇可以通过改变肥胖OLETF大鼠的营养物质代谢谱来预防肥胖。
Resveratrol (trans-3,4′,5-trihydroxystilbene) is a naturally occurring phytoalexin produced by plants in response to various stresses. Several studies have shown that resveratrol is present in significant amounts in a variety of human diets, including wines, grapes, berries, and peanuts, and it possesses several beneficial health properties, such as atheroprotective, anti-obesity, anti-cancer, anti-inflammatory and antioxidant activities. In this study, we evaluated the effect of resveratrol on the pathogenesis of obesity and the metabolic profile of nutrients in non-high fat-fed obese OLETF rats. Although lipid parameters in the serum and liver were not changed, the accumulation of abdominal white adipose tissues was markedly prevented in resveratrol diet-fed OLETF rats after 4 weeks of feeding. The results of the respiratory gas analysis indicated that dietary resveratrol induced the partial enhancement of fat metabolism and sparing actions for carbohydrate and protein at 1 week and 3 weeks of feeding in OLETF rats. Additionally, the adipose mRNA level of carnitine palmitoyltransferase in the resveratrol diet-fed OLETF rats was higher than the control rats after 4 weeks of feeding. Our study demonstrated that dietary resveratrol can prevent obesity through a change in the metabolic profile of nutrients in obese OLETF rats.